BACKGROUND: The CHADS₂ score (congestive heart failure, hypertension, age >75 years, diabetes, and previous stroke/transient ischemic attack) is used for the risk stratification of strokes in patients with atrial fibrillation (AF). OBJECTIVE: This study aimed to investigate the associations between the CHADS₂ score, atrial substrate, and outcome of catheter ablation in patients with paroxysmal AF. METHODS: A total of 247 paroxysmal AF patients who received catheter ablation were enrolled. The patients were divided into 3 groups according to their CHADS₂ score (group 1: score 0, group 2: score 1 to 2, and group 3: score 3 to 6). The bi-atrial substrate properties and outcome of catheter ablation were analyzed. RESULTS: The CHADS₂ scores in these 3 groups were 0 (group 1), 1.24 ± 0.48 (group 2), and 3.60 ± 0.83 (group 3), respectively. The left atrial voltage became lower (group 1 vs. 2 vs. 3 = 2.08 ± 0.73 mV vs. 1.80 ± 0.81 mV vs. 1.06 ± 0.69 mV) and the activation time longer (group 1 vs. 2 vs. 3 = 93.4 ± 17.7 ms vs. 101.9 ± 21.2 ms vs. 112.2 ± 21.7 ms), whereas the CHADS₂ score increased. During a follow-up of 17.3 ± 7.0 months, 23.1% of the study population suffered from recurrences. The recurrence rates of these 3 groups were 13.0% (group 1), 27.6% (group 2), and 45.9% (group 3), respectively. The groups of different CHADS₂ scores remained as the independent predictor of recurrence in the multivariate analysis. CONCLUSION: A high CHADS₂ score was associated with different left atrial substrate properties and a poor outcome after catheter ablation of paroxysmal AF.
BACKGROUND: The CHADS₂ score (congestive heart failure, hypertension, age >75 years, diabetes, and previous stroke/transient ischemic attack) is used for the risk stratification of strokes in patients with atrial fibrillation (AF). OBJECTIVE: This study aimed to investigate the associations between the CHADS₂ score, atrial substrate, and outcome of catheter ablation in patients with paroxysmal AF. METHODS: A total of 247 paroxysmal AFpatients who received catheter ablation were enrolled. The patients were divided into 3 groups according to their CHADS₂ score (group 1: score 0, group 2: score 1 to 2, and group 3: score 3 to 6). The bi-atrial substrate properties and outcome of catheter ablation were analyzed. RESULTS: The CHADS₂ scores in these 3 groups were 0 (group 1), 1.24 ± 0.48 (group 2), and 3.60 ± 0.83 (group 3), respectively. The left atrial voltage became lower (group 1 vs. 2 vs. 3 = 2.08 ± 0.73 mV vs. 1.80 ± 0.81 mV vs. 1.06 ± 0.69 mV) and the activation time longer (group 1 vs. 2 vs. 3 = 93.4 ± 17.7 ms vs. 101.9 ± 21.2 ms vs. 112.2 ± 21.7 ms), whereas the CHADS₂ score increased. During a follow-up of 17.3 ± 7.0 months, 23.1% of the study population suffered from recurrences. The recurrence rates of these 3 groups were 13.0% (group 1), 27.6% (group 2), and 45.9% (group 3), respectively. The groups of different CHADS₂ scores remained as the independent predictor of recurrence in the multivariate analysis. CONCLUSION: A high CHADS₂ score was associated with different left atrial substrate properties and a poor outcome after catheter ablation of paroxysmal AF.
Authors: Jana Mareike Nührich; Karl-Heinz Kuck; Dietrich Andresen; Daniel Steven; Stefan G Spitzer; Ellen Hoffmann; Burghard Schumacher; Lars Eckardt; Johannes Brachmann; Thorsten Lewalter; Matthias Hochadel; Jochen Senges; Stephan Willems; Boris A Hoffmann Journal: Clin Res Cardiol Date: 2014-12-24 Impact factor: 5.460
Authors: Jeffrey J Goldberger; Rishi Arora; David Green; Philip Greenland; Daniel C Lee; Donald M Lloyd-Jones; Michael Markl; Jason Ng; Sanjiv J Shah Journal: Circulation Date: 2015-07-28 Impact factor: 29.690
Authors: Hong Euy Lim; Jin Oh Na; Sung Il Im; Cheol Ung Choi; Seong Hwan Kim; Jin Won Kim; Eung Ju Kim; Seong Woo Han; Seung-Woon Rha; Chang Gyu Park; Hong Seog Seo; Dong Joo Oh; Chun Hwang Journal: Korean J Intern Med Date: 2015-10-30 Impact factor: 2.884