Literature DB >> 21401577

The tumour necrosis factor/TNF receptor superfamily: therapeutic targets in autoimmune diseases.

D S Vinay1, B S Kwon.   

Abstract

Autoimmune diseases are characterized by the body's ability to mount immune attacks on self. This results from recognition of self-proteins and leads to organ damage due to increased production of pathogenic inflammatory molecules and autoantibodies. Over the years, several new potential therapeutic targets have been identified in autoimmune diseases, notable among which are members of the tumour necrosis factor (TNF) superfamily. Here, we review the evidence that certain key members of this superfamily can augment/suppress autoimmune diseases.
© 2011 The Authors. Clinical and Experimental Immunology © 2011 British Society for Immunology.

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Year:  2011        PMID： 21401577      PMCID： PMC3087907          DOI： 10.1111/j.1365-2249.2011.04375.x

Source DB:  PubMed          Journal:  Clin Exp Immunol        ISSN： 0009-9104            Impact factor:   4.330


  195 in total

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