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Literature DB >> 21399623

Receptor for advanced glycation end products binds to phosphatidylserine and assists in the clearance of apoptotic cells.

Mei He¹, Hiroshi Kubo, Konosuke Morimoto, Naoya Fujino, Takaya Suzuki, Toru Takahasi, Mitsuhiro Yamada, Mutsuo Yamaya, Tomoyuki Maekawa, Yasuhiko Yamamoto, Hiroshi Yamamoto.

Abstract

Clearance of apoptotic cells is necessary for tissue development, homeostasis and resolution of inflammation. The uptake of apoptotic cells is initiated by an 'eat-me' signal, such as phosphatidylserine, on the cell surface and phagocytes recognize the signal by using specific receptors. In this study, we show that the soluble form of the receptor for advanced glycation end products (RAGE) binds to phosphatidylserine as well as to the apoptotic thymocytes. RAGE-deficient (Rage(-/-)) alveolar macrophages showed impaired phagocytosis of apoptotic thymocytes and defective clearance of apoptotic neutrophils in Rage(-/-) mice. Our results indicate that RAGE functions as a phosphatidylserine receptor and assists in the clearance of apoptotic cells.

Entities: Chemical Disease Gene Species

Mesh：

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Year: 2011 PMID： 21399623 PMCID： PMC3077249 DOI： 10.1038/embor.2011.28

Source DB: PubMed Journal: EMBO Rep ISSN： 1469-221X Impact factor: 8.807

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