Literature DB >> 21397853

SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF.

Paul T Schumacker1.   

Abstract

In this issue of Cancer Cell, Finley and coworkers report that the genetic loss of the deacetylase SIRT3 leads to metabolic reprogramming toward glycolysis. This shift is mediated by an increase in cellular reactive oxygen species (ROS) generation that amplifies HIF-α stabilization and HIF-dependent gene expression, thereby driving the tumor phenotype.
Copyright © 2011 Elsevier Inc. All rights reserved.

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Year:  2011        PMID： 21397853      PMCID： PMC3087169          DOI： 10.1016/j.ccr.2011.03.001

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  9 in total

1.  On respiratory impairment in cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-08-10       Impact factor: 47.728

2.  SIRT3 opposes reprogramming of cancer cell metabolism through HIF1α destabilization.

Authors:  Lydia W S Finley; Arkaitz Carracedo; Jaewon Lee; Amanda Souza; Ainara Egia; Jiangwen Zhang; Julie Teruya-Feldstein; Paula I Moreira; Sandra M Cardoso; Clary B Clish; Pier Paolo Pandolfi; Marcia C Haigis
Journal:  Cancer Cell       Date:  2011-03-08       Impact factor: 31.743

Review 3.  A tumor suppressor SIRTainty.

Authors:  Paul T Schumacker
Journal:  Cancer Cell       Date:  2010-01-19       Impact factor: 31.743

4.  SIRT3 is a mitochondria-localized tumor suppressor required for maintenance of mitochondrial integrity and metabolism during stress.

Authors:  Hyun-Seok Kim; Krish Patel; Kristi Muldoon-Jacobs; Kheem S Bisht; Nukhet Aykin-Burns; J Daniel Pennington; Riet van der Meer; Phuongmai Nguyen; Jason Savage; Kjerstin M Owens; Athanassios Vassilopoulos; Ozkan Ozden; Seong-Hoon Park; Keshav K Singh; Sarki A Abdulkadir; Douglas R Spitz; Chu-Xia Deng; David Gius
Journal:  Cancer Cell       Date:  2010-01-19       Impact factor: 31.743

Review 5.  HIF-1: upstream and downstream of cancer metabolism.

Authors:  Gregg L Semenza
Journal:  Curr Opin Genet Dev       Date:  2009-11-26       Impact factor: 5.578

6.  Mitochondrial reactive oxygen species trigger hypoxia-induced transcription.

Authors:  N S Chandel; E Maltepe; E Goldwasser; C E Mathieu; M C Simon; P T Schumacker
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-29       Impact factor: 11.205

Review 7.  Understanding the Warburg effect: the metabolic requirements of cell proliferation.

Authors:  Matthew G Vander Heiden; Lewis C Cantley; Craig B Thompson
Journal:  Science       Date:  2009-05-22       Impact factor: 47.728

Review 8.  Defining the role of hypoxia-inducible factor 1 in cancer biology and therapeutics.

Authors:  G L Semenza
Journal:  Oncogene       Date:  2009-11-30       Impact factor: 9.867

9.  SIRT3 interacts with the daf-16 homolog FOXO3a in the mitochondria, as well as increases FOXO3a dependent gene expression.

Authors:  Kristi Muldoon Jacobs; J Daniel Pennington; Kheem S Bisht; Nukhet Aykin-Burns; Hyun-Seok Kim; Mark Mishra; Lunching Sun; Phuongmai Nguyen; Bong-Hyun Ahn; Jaime Leclerc; Chu-Xia Deng; Douglas R Spitz; David Gius
Journal:  Int J Biol Sci       Date:  2008-09-05       Impact factor: 6.580
  9 in total
  32 in total

Review 1.  Manganese superoxide dismutase (SOD2): is there a center in the universe of mitochondrial redox signaling?

Authors:  Xianghui Zou; Bianca A Ratti; Joseph Gerald O'Brien; Sueli O Lautenschlager; David R Gius; Marcelo G Bonini; Yueming Zhu
Journal:  J Bioenerg Biomembr       Date:  2017-06-14       Impact factor: 2.945

2.  Programmed death ligand 1 promotes lymph node metastasis and glucose metabolism in cervical cancer by activating integrin β4/SNAI1/SIRT3 signaling pathway.

Authors:  Shaojia Wang; Jiajia Li; Jie Xie; Fei Liu; Yachen Duan; Yong Wu; Shenglin Huang; Xianghuo He; Ziliang Wang; Xiaohua Wu
Journal:  Oncogene       Date:  2018-04-30       Impact factor: 9.867

3.  Systemic application of honokiol prevents cisplatin ototoxicity without compromising its antitumor effect.

Authors:  Xiaodong Tan; Yingjie Zhou; Aditi Agarwal; Michelle Lim; Yingyue Xu; Yueming Zhu; Joseph O'Brien; Elizabeth Tran; Jing Zheng; David Gius; Claus-Peter Richter
Journal:  Am J Cancer Res       Date:  2020-12-01       Impact factor: 6.166

4.  SIRT3 protects endothelial cells from high glucose-induced cytotoxicity.

Authors:  Guodong Liu; Mingming Cao; Ying Xu; Yanbo Li
Journal:  Int J Clin Exp Pathol       Date:  2015-01-01

5.  NADPH oxidase DUOX1 and DUOX2 but not NOX4 are independent predictors in hepatocellular carcinoma after hepatectomy.

Authors:  Can-Liang Lu; Ji-Liang Qiu; Pin-Zhu Huang; Ru-Hai Zou; Jian Hong; Bin-Kui Li; Gui-Hua Chen; Yun-Fei Yuan
Journal:  Tumour Biol       Date:  2011-09-14

Review 6.  Interplay Between SIRT-3, Metabolism and Its Tumor Suppressor Role in Hepatocellular Carcinoma.

Authors:  Serena De Matteis; Anna Maria Granato; Roberta Napolitano; Chiara Molinari; Martina Valgiusti; Daniele Santini; Francesco Giuseppe Foschi; Giorgio Ercolani; Umberto Vespasiani Gentilucci; Luca Faloppi; Mario Scartozzi; Giovanni Luca Frassineti; Andrea Casadei Gardini
Journal:  Dig Dis Sci       Date:  2017-05-19       Impact factor: 3.199

7.  The biphasic redox sensing of SENP3 accounts for the HIF-1 transcriptional activity shift by oxidative stress.

Authors:  Ying Wang; Jie Yang; Kai Yang; Hui Cang; Xin-zhi Huang; Hui Li; Jing Yi
Journal:  Acta Pharmacol Sin       Date:  2012-06-11       Impact factor: 6.150

8.  Sirtuin 3 Deregulation Promotes Pulmonary Fibrosis.

Authors:  Meredith L Sosulski; Rafael Gongora; Carol Feghali-Bostwick; Joseph A Lasky; Cecilia G Sanchez
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2017-05-01       Impact factor: 6.053

Review 9.  Manganese Superoxide Dismutase Acetylation and Dysregulation, Due to Loss of SIRT3 Activity, Promote a Luminal B-Like Breast Carcinogenic-Permissive Phenotype.

Authors:  Xianghui Zou; Cesar Augusto Santa-Maria; Joseph O'Brien; David Gius; Yueming Zhu
Journal:  Antioxid Redox Signal       Date:  2016-04-15       Impact factor: 8.401

10.  Sirtuin-3 modulates Bak- and Bax-dependent apoptosis.

Authors:  Manish Verma; Nataly Shulga; John G Pastorino
Journal:  J Cell Sci       Date:  2012-10-29       Impact factor: 5.285
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