Literature DB >> 20129243

A tumor suppressor SIRTainty.

Paul T Schumacker1.   

Abstract

Sirtuin deacetylases are linked to longevity, aging, and stress responses. In this issue of Cancer Cell, Kim et al. show that SIRT3 functions as a tumor suppressor by enhancing the expression of mitochondrial MnSOD. Loss of SIRT3 leads to increased mitochondrial ROS, which then enhances cellular transformation and tumor growth. Copyright (c) 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20129243     DOI： 10.1016/j.ccr.2009.12.032

Source DB:  PubMed          Journal:  Cancer Cell        ISSN： 1535-6108            Impact factor:   31.743


  10 in total

1.  RelB Expression Determines the Differential Effects of Ascorbic Acid in Normal and Cancer Cells.

Authors:  Xiaowei Wei; Yong Xu; Fang Fang Xu; Luksana Chaiswing; David Schnell; Teresa Noel; Chi Wang; Jinfei Chen; Daret K St Clair; William H St Clair
Journal:  Cancer Res       Date:  2017-01-20       Impact factor: 12.701

2.  SIRT3 controls cancer metabolic reprogramming by regulating ROS and HIF.

Authors:  Paul T Schumacker
Journal:  Cancer Cell       Date:  2011-03-08       Impact factor: 31.743

3.  Altered expression of SIRT gene family in head and neck squamous cell carcinoma.

Authors:  Chi-Chih Lai; Pai-Mei Lin; Sheng-Fung Lin; Cheng-Hsien Hsu; Hsin-Ching Lin; Ming-Luen Hu; Cheng-Ming Hsu; Ming-Yu Yang
Journal:  Tumour Biol       Date:  2013-03-12

4.  Role of SIRT3 in the regulation of redox balance during oral carcinogenesis.

Authors:  I-Chieh Chen; Wei-Fan Chiang; Shyun-Yeu Liu; Pei-Fen Chen; Hung-Che Chiang
Journal:  Mol Cancer       Date:  2013-06-23       Impact factor: 27.401

5.  Sirtuins, bioageing, and cancer.

Authors:  D McGuinness; D H McGuinness; J A McCaul; P G Shiels
Journal:  J Aging Res       Date:  2011-06-30

6.  Integrative DNA methylation and gene expression analyses identify DNA packaging and epigenetic regulatory genes associated with low motility sperm.

Authors:  Sara E Pacheco; E Andres Houseman; Brock C Christensen; Carmen J Marsit; Karl T Kelsey; Mark Sigman; Kim Boekelheide
Journal:  PLoS One       Date:  2011-06-02       Impact factor: 3.240

7.  SIRT3 & SIRT7: Potential Novel Biomarkers for Determining Outcome in Pancreatic Cancer Patients.

Authors:  Liane M McGlynn; Simon McCluney; Nigel B Jamieson; Jackie Thomson; Alasdair I MacDonald; Karin Oien; Euan J Dickson; C Ross Carter; Colin J McKay; Paul G Shiels
Journal:  PLoS One       Date:  2015-06-29       Impact factor: 3.240

Review 8.  SOD1, an unexpected novel target for cancer therapy.

Authors:  Luena Papa; Giovanni Manfredi; Doris Germain
Journal:  Genes Cancer       Date:  2014-04

9.  Serotonin activates glycolysis and mitochondria biogenesis in human breast cancer cells through activation of the Jak1/STAT3/ERK1/2 and adenylate cyclase/PKA, respectively.

Authors:  Mauro Sola-Penna; Larissa P Paixão; Jessica R Branco; Alan C Ochioni; Jamille M Albanese; Davi M Mundim; Daniela Baptista-de-Souza; Claudia P Figueiredo; Wagner S Coelho; Mariah C Marcondes; Patricia Zancan
Journal:  Br J Cancer       Date:  2019-12-10       Impact factor: 7.640

Review 10.  Function of the SIRT3 mitochondrial deacetylase in cellular physiology, cancer, and neurodegenerative disease.

Authors:  Aneesa Ansari; Md Shahedur Rahman; Subbroto K Saha; Forhad K Saikot; Akash Deep; Ki-Hyun Kim
Journal:  Aging Cell       Date:  2016-09-29       Impact factor: 9.304
  10 in total

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