OBJECTIVE: To determine the electrophysiological characteristics of frontotemporal dementia (FTD) and the distinction with Alzheimer's disease (AD). METHODS: We performed analyses of global field power (GFP) which is a measure of whole brain electric field strength, and EEG neuroimaging analyses with sLORETA (standardized low resolution electromagnetic tomography), in the mild stages of FTD (n = 19; mean age = 68.11 ± 7.77) and AD (n = 19; mean age = 69.42 ± 9.57) patients, and normal control (NC) subjects (n = 22; mean age = 66.13 ± 6.02). RESULTS: In the GFP analysis, significant group effects were observed in the delta (1.5-6.0 Hz), alpha1 (8.5-10.0 Hz), and beta1 (12.5-18.0 Hz) bands. In sLORETA analysis, differences in activity were observed in the alpha1 band (NC > FTD) in the orbital frontal and temporal lobe, in the delta band (AD>NC) in widespread areas including the frontal lobe, and in the beta1 band (FTD > AD) in the parietal lobe and sensorimotor area. CONCLUSIONS: Differential patterns of brain regions and EEG frequency bands were observed between the FTD and AD groups in terms of pathological activity. SIGNIFICANCE: FTD and AD patients in the early stages displayed different patterns in the cortical localization of oscillatory activity across different frequency bands.
OBJECTIVE: To determine the electrophysiological characteristics of frontotemporal dementia (FTD) and the distinction with Alzheimer's disease (AD). METHODS: We performed analyses of global field power (GFP) which is a measure of whole brain electric field strength, and EEG neuroimaging analyses with sLORETA (standardized low resolution electromagnetic tomography), in the mild stages of FTD (n = 19; mean age = 68.11 ± 7.77) and AD (n = 19; mean age = 69.42 ± 9.57) patients, and normal control (NC) subjects (n = 22; mean age = 66.13 ± 6.02). RESULTS: In the GFP analysis, significant group effects were observed in the delta (1.5-6.0 Hz), alpha1 (8.5-10.0 Hz), and beta1 (12.5-18.0 Hz) bands. In sLORETA analysis, differences in activity were observed in the alpha1 band (NC > FTD) in the orbital frontal and temporal lobe, in the delta band (AD>NC) in widespread areas including the frontal lobe, and in the beta1 band (FTD > AD) in the parietal lobe and sensorimotor area. CONCLUSIONS: Differential patterns of brain regions and EEG frequency bands were observed between the FTD and AD groups in terms of pathological activity. SIGNIFICANCE: FTD and ADpatients in the early stages displayed different patterns in the cortical localization of oscillatory activity across different frequency bands.
Authors: Claudio Babiloni; Claudio Del Percio; Marina Boccardi; Roberta Lizio; Susanna Lopez; Filippo Carducci; Nicola Marzano; Andrea Soricelli; Raffaele Ferri; Antonio Ivano Triggiani; Annapaola Prestia; Serenella Salinari; Paul E Rasser; Erol Basar; Francesco Famà; Flavio Nobili; Görsev Yener; Derya Durusu Emek-Savaş; Loreto Gesualdo; Ciro Mundi; Paul M Thompson; Paolo M Rossini; Giovanni B Frisoni Journal: Neurobiol Aging Date: 2014-09-21 Impact factor: 4.673
Authors: Heinrich Garn; Carmina Coronel; Markus Waser; Georg Caravias; Gerhard Ransmayr Journal: J Neural Transm (Vienna) Date: 2017-02-27 Impact factor: 3.575
Authors: Miralena I Tomescu; Tonia A Rihs; Maya Roinishvili; F Isik Karahanoglu; Maude Schneider; Sarah Menghetti; Dimitri Van De Ville; Andreas Brand; Eka Chkonia; Stephan Eliez; Michael H Herzog; Christoph M Michel; Céline Cappe Journal: Schizophr Res Cogn Date: 2015-05-27