Literature DB >> 21394502

Cancer physics: diagnostics based on damped cellular elastoelectrical vibrations in microtubules.

Jiří Pokorný1, Clarbruno Vedruccio, Michal Cifra, Ondřej Kučera.   

Abstract

This paper describes a proposed biophysical mechanism of a novel diagnostic method for cancer detection developed recently by Vedruccio. The diagnostic method is based on frequency selective absorption of electromagnetic waves by malignant tumors. Cancer is connected with mitochondrial malfunction (the Warburg effect) suggesting disrupted physical mechanisms. In addition to decreased energy conversion and nonutilized energy efflux, mitochondrial malfunction is accompanied by other negative effects in the cell. Diminished proton space charge layer and the static electric field around the outer membrane result in a lowered ordering level of cellular water and increased damping of microtubule-based cellular elastoelectrical vibration states. These changes manifest themselves in a dip in the amplitude of the signal with the fundamental frequency of the nonlinear microwave oscillator-the core of the diagnostic device-when coupled to the investigated cancerous tissue via the near-field. The dip is not present in the case of healthy tissue.

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Year:  2011        PMID: 21394502     DOI: 10.1007/s00249-011-0688-1

Source DB:  PubMed          Journal:  Eur Biophys J        ISSN: 0175-7571            Impact factor:   1.733


  56 in total

1.  On the origin of cancer cells.

Authors:  O WARBURG
Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

2.  Anisotropic elastic properties of microtubules.

Authors:  J A Tuszyński; T Luchko; S Portet; J M Dixon
Journal:  Eur Phys J E Soft Matter       Date:  2005-04-06       Impact factor: 1.890

3.  A mitochondria-K+ channel axis is suppressed in cancer and its normalization promotes apoptosis and inhibits cancer growth.

Authors:  Sébastien Bonnet; Stephen L Archer; Joan Allalunis-Turner; Alois Haromy; Christian Beaulieu; Richard Thompson; Christopher T Lee; Gary D Lopaschuk; Lakshmi Puttagunta; Sandra Bonnet; Gwyneth Harry; Kyoko Hashimoto; Christopher J Porter; Miguel A Andrade; Bernard Thebaud; Evangelos D Michelakis
Journal:  Cancer Cell       Date:  2007-01       Impact factor: 31.743

4.  "Nanosized voltmeter" enables cellular-wide electric field mapping.

Authors:  Katherine M Tyner; Raoul Kopelman; Martin A Philbert
Journal:  Biophys J       Date:  2007-05-18       Impact factor: 4.033

5.  Spectroscopic studies of solutes in aqueous solution.

Authors:  Bing-hua Chai; Jian-ming Zheng; Qing Zhao; Gerald H Pollack
Journal:  J Phys Chem A       Date:  2008-02-26       Impact factor: 2.781

6.  A novel method of assessing carcinoma cell proliferation by biophoton emission.

Authors:  M Takeda; Y Tanno; M Kobayashi; M Usa; N Ohuchi; S Satomi; H Inaba
Journal:  Cancer Lett       Date:  1998-05-15       Impact factor: 8.679

7.  Electromagnetic field of microtubules: effects on transfer of mass particles and electrons.

Authors:  Jiří Pokorný; Jiří Hašek; František Jelínek
Journal:  J Biol Phys       Date:  2005-12       Impact factor: 1.365

8.  The nature of the clear zone around microtubules.

Authors:  H Stebbings; C Hunt
Journal:  Cell Tissue Res       Date:  1982       Impact factor: 5.249

9.  Non-invasive detection of prostate cancer by electromagnetic interaction.

Authors:  Carlo Bellorofonte; Clarbruno Vedruccio; Pietro Tombolini; Michele Ruoppolo; Andrea Tubaro
Journal:  Eur Urol       Date:  2005-01       Impact factor: 20.096

Review 10.  Warburg, me and Hexokinase 2: Multiple discoveries of key molecular events underlying one of cancers' most common phenotypes, the "Warburg Effect", i.e., elevated glycolysis in the presence of oxygen.

Authors:  Peter L Pedersen
Journal:  J Bioenerg Biomembr       Date:  2007-06       Impact factor: 2.945

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  13 in total

1.  Coupled oscillations of a protein microtubule immersed in cytoplasm: an orthotropic elastic shell modeling.

Authors:  Farhang Daneshmand; Marco Amabili
Journal:  J Biol Phys       Date:  2012-02-18       Impact factor: 1.365

2.  Vibrational dynamics of bio- and nano-filaments in viscous solution subjected to ultrasound: implications for microtubules.

Authors:  Abdorreza Samarbakhsh; Jack A Tuszynski
Journal:  Eur Biophys J       Date:  2011-05-28       Impact factor: 1.733

3.  Electromechanical vibration of microtubules and its application in biosensors.

Authors:  Si Li; Chengyuan Wang; Perumal Nithiarasu
Journal:  J R Soc Interface       Date:  2019-02-28       Impact factor: 4.118

4.  Tissue resonance interaction accurately detects colon lesions: A double-blind pilot study.

Authors:  Maria P Dore; Marcello O Tufano; Giovanni M Pes; Marianna Cuccu; Valentina Farina; Alessandra Manca; David Y Graham
Journal:  World J Gastroenterol       Date:  2015-07-07       Impact factor: 5.742

5.  Modification of S. cerevisiae Growth Dynamics Using Low Frequency Electromagnetic Fields in the 1-2 kHz Range.

Authors:  Ján Barabáš; Roman Radil; Ivona Malíková
Journal:  Biomed Res Int       Date:  2015-07-28       Impact factor: 3.411

Review 6.  Mitochondrial Dysfunction and Disturbed Coherence: Gate to Cancer.

Authors:  Jiří Pokorný; Jan Pokorný; Alberto Foletti; Jitka Kobilková; Jan Vrba; Jan Vrba
Journal:  Pharmaceuticals (Basel)       Date:  2015-09-30

7.  Noninvasive electromagnetic detection of bladder cancer.

Authors:  Luigi Cormio; Clarbruno Vedruccio; Giorgio Leucci; Paolo Massenio; Giuseppe Di Fino; Vincenzo Cavaliere; Giuseppe Carrieri
Journal:  ISRN Urol       Date:  2014-01-16

8.  Biophysical insights into cancer transformation and treatment.

Authors:  Jiří Pokorný; Alberto Foletti; Jitka Kobilková; Anna Jandová; Jan Vrba; Jan Vrba; Martina Nedbalová; Aleš Čoček; Andrea Danani; Jack A Tuszyński
Journal:  ScientificWorldJournal       Date:  2013-06-11

Review 9.  Electric fields generated by synchronized oscillations of microtubules, centrosomes and chromosomes regulate the dynamics of mitosis and meiosis.

Authors:  Yue Zhao; Qimin Zhan
Journal:  Theor Biol Med Model       Date:  2012-07-02       Impact factor: 2.432

Review 10.  Long range physical cell-to-cell signalling via mitochondria inside membrane nanotubes: a hypothesis.

Authors:  Felix Scholkmann
Journal:  Theor Biol Med Model       Date:  2016-06-06       Impact factor: 2.432

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