Tao Jiang1, Guipeng Liu, Ling Huang, Haining Ma, Shulan Zhang. 1. Department of Gynecology and Obstetrics, Shengjing Hospital of China Medical University, No. 36, Sanhao Street, Heping District, Shenyang, Liaoning Province 110004, China. jiangt@sj-hospital.org
Abstract
OBJECTIVES: Caesarean scar pregnancy (CSP) is a very rare and dangerous form of pregnancy because of the increased risk of rupture and excessive hemorrhage. There is currently no consensus on the treatment. We studied if methotrexate (MTX) therapy followed by suction curettage followed by Foley tamponade was a viable treatment for patients with CSP. STUDY DESIGN: Forty-five patients with CSP in our hospital received a single dose of 50mg/m(2) MTX by intramuscular injection. If gestational cardiac activity was seen on transvaginal ultrasound, local injection of MTX was given. After 7 days, suction curettage was performed to remove the retained products of conception and blood clot (CSP mass) under transabdominal sonography (TAS) guidance. After the suction curettage, a Foley catheter balloon was placed into the isthmic portion of cervix. RESULTS: Forty-two subjects were successfully treated and 3 subjects failed treatment. The mean estimated blood loss of all 45 patients was 706.89 ± 642.08 (100-3000)ml. The resolution time of the serum β-hCG was 20.62 ± 5.41 (9-33) days. The time to CSP mass disappearance was 12.57 ± 4.37 (8-25) days. CONCLUSIONS: MTX administration followed by suction curettage followed by Foley tamponade was an effective treatment for caesarean scar pregnancy.
OBJECTIVES: Caesarean scar pregnancy (CSP) is a very rare and dangerous form of pregnancy because of the increased risk of rupture and excessive hemorrhage. There is currently no consensus on the treatment. We studied if methotrexate (MTX) therapy followed by suction curettage followed by Foley tamponade was a viable treatment for patients with CSP. STUDY DESIGN: Forty-five patients with CSP in our hospital received a single dose of 50mg/m(2) MTX by intramuscular injection. If gestational cardiac activity was seen on transvaginal ultrasound, local injection of MTX was given. After 7 days, suction curettage was performed to remove the retained products of conception and blood clot (CSP mass) under transabdominal sonography (TAS) guidance. After the suction curettage, a Foley catheter balloon was placed into the isthmic portion of cervix. RESULTS: Forty-two subjects were successfully treated and 3 subjects failed treatment. The mean estimated blood loss of all 45 patients was 706.89 ± 642.08 (100-3000)ml. The resolution time of the serum β-hCG was 20.62 ± 5.41 (9-33) days. The time to CSP mass disappearance was 12.57 ± 4.37 (8-25) days. CONCLUSIONS:MTX administration followed by suction curettage followed by Foley tamponade was an effective treatment for caesarean scar pregnancy.
Authors: I P M Jordans; C Verberkt; R A De Leeuw; C M Bilardo; T Van Den Bosch; T Bourne; H A M Brölmann; M Dueholm; W J K Hehenkamp; N Jastrow; D Jurkovic; A Kaelin Agten; R Mashiach; O Naji; E Pajkrt; D Timmerman; O Vikhareva; L F Van Der Voet; J A F Huirne Journal: Ultrasound Obstet Gynecol Date: 2022-04 Impact factor: 8.678