Literature DB >> 21391555

Direct alkylation of heteroaryls using potassium alkyl- and alkoxymethyltrifluoroborates.

Gary A Molander1, Virginie Colombel, Valerie A Braz.   

Abstract

A direct alkylation of various heteroaryls using stoichiometric potassium alkyl- and alkoxymethyltrifluoroborates has been developed. This method leads to the synthesis of complex substituted heterocycles, which have been obtained with yields up to 89%.

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Year:  2011        PMID： 21391555      PMCID： PMC3069859          DOI： 10.1021/ol2003572

Source DB:  PubMed          Journal:  Org Lett        ISSN： 1523-7052            Impact factor:   6.005


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7.  Late-Stage C-H Alkylation of Heterocycles and 1,4-Quinones via Oxidative Homolysis of 1,4-Dihydropyridines.

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