Literature DB >> 21389783

Hes1 expression and CYLD repression are essential events downstream of Notch1 in T-cell leukemia.

Teresa D'Altri1, Jessica Gonzalez, Iannis Aifantis, Lluis Espinosa, Anna Bigas.   

Abstract

Notch activation is a current event in T Acute Lymphoblastic Leukemia (T-ALL) but the downstream elements that are able to support Notch-dependent leukemias are not well characterized. We have recently shown that the Notch-Hes1-CYLD-NFkB axis is crucial in the maintenance of T-ALL, but detailed evaluation of the contribution of each one of these elements is still missing. Here we use a Notch1-induced leukemia in vivo model to study the effect of silencing the Notch-target gene, Hes1, or over-expressing the Hes1-target, CYLD. We here show that both strategies completely abolish the ability of constitutive active Notch1 to generate T-ALL.

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Year:  2011        PMID： 21389783      PMCID： PMC3974883          DOI： 10.4161/cc.10.7.15067

Source DB:  PubMed          Journal:  Cell Cycle        ISSN： 1551-4005            Impact factor:   4.534


  34 in total

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