Literature DB >> 21388191

Maklamicin, an antibacterial polyketide from an endophytic Micromonospora sp.

Yasuhiro Igarashi1, Hiromu Ogura, Kazuo Furihata, Naoya Oku, Chantra Indananda, Arinthip Thamchaipenet.   

Abstract

A new spirotetronate-class polyketide, maklamicin (1), was isolated from the culture extract of an endophytic actinomycete of the genus Micromonospora. The structure and relative configuration of 1 were elucidated by interpretation of NMR and other spectroscopic data, and the absolute configuration was determined using the modified Mosher method. Maklamicin (1) showed strong to modest antimicrobial activity against Gram-positive bacteria.

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Year:  2011        PMID： 21388191     DOI： 10.1021/np100727h

Source DB:  PubMed          Journal:  J Nat Prod        ISSN： 0163-3864            Impact factor:   4.050


  18 in total

1.  Continuing hunt for endophytic actinomycetes as a source of novel biologically active metabolites.

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5.  Micromonospora endophytica sp. nov., an endophytic actinobacteria of Thai upland rice (Oryza sativa).

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6.  Micromonospora is a normal occupant of actinorhizal nodules.

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8.  Fusarisetin A: Scalable Total Synthesis and Related Studies.

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9.  Synthetic Strategies Toward the Decalin Motif of Maklamicin and Related Spirotetronates.

Authors:  Michelle H Lacoske; Jing Xu; Noel Mansour; Chao Gao; Emmanuel A Theodorakis
Journal:  Org Chem Front       Date:  2015-04-01       Impact factor: 5.281

10.  Fusarisetins: Structure-function studies on a novel class of cell migration inhibitors.

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