| Literature DB >> 21384853 |
François Otis1, Charles Racine-Berthiaume, Normand Voyer.
Abstract
Analogues of a synthetic ion channel made from a helical peptide were used to study the mechanism of cation translocation within bilayer membranes. Derivatives bearing two, three, four, and six crown ethers used as ion relays were synthesized, and their transport abilities across lipid bilayers were measured. The results showed that the maximum distance a sodium ion is permitted to travel between two binding sites within a lipid bilayer environment is 11 Å.Entities:
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Year: 2011 PMID： 21384853 DOI： 10.1021/ja110336s
Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419