| Literature DB >> 2138035 |
F J Van Kuijk1, L L Holte, E A Dratz.
Abstract
4-Hydroxynonenal and 4-hydroxyhexenal are cytotoxic aldehydic products of lipid peroxidation with high biological activity. Peroxidation of n - 6 fatty acids produces 4-hydroxynonenal, but the origin of 4-hydroxyhexenal has been uncertain. We now present evidence that 4-hydroxyhexenal is generated by oxidation of docosahexaenoic acid, the most abundant n-3 fatty acid in tissues.Entities:
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Year: 1990 PMID： 2138035 DOI： 10.1016/0005-2760(90)90118-h
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002