AIM: Most studies have reported that circulating levels of adiponectin are negatively correlated with the body mass index (BMI), and hypoadiponectinemia is related to cardiometabolic disorders; however, not all obese subjects have hypoadiponectinemia. The present study investigated circulating adiponectin levels and fat distribution, i.e. subcutaneous fat area (SFA) and visceral fat area (VFA), in obese subjects. METHODS: Sixty-eight obese Korean subjects underwent fat distribution by computed tomography (CT) scan and laboratory tests including circulating total adiponectin levels (APN) and circulating high molecular weight adiponectin levels (HMW-APN). RESULTS: Log-APN and log-HMW-APN did not correlate with log-BMI either in obese males or females in this study; however, log-APN significantly and negatively correlated with log-VFA both in obese males (r=-0.691, p=0.009) and females (r=-0.319, p=0.002), and log-HMW-APN also correlated negatively with log-VFA both in obese males (r=-0.650, p=0.016) and females (r=-0.370, p=0.005). Log-VFA was a significant determinant of log-APN and log-HMW-APN in obese subjects. In contrast, neither log-APN nor log-HMW-APN was significantly correlated with log-SFA in obese males and females. CONCLUSIONS: The present study demonstrated that APN and HMW-APN correlated with VFA, but not BMI and SFA, in obese subjects, and suggest that hypoadiponectinemia may represent dysfunction of adipose tissue in obesity.
AIM: Most studies have reported that circulating levels of adiponectin are negatively correlated with the body mass index (BMI), and hypoadiponectinemia is related to cardiometabolic disorders; however, not all obese subjects have hypoadiponectinemia. The present study investigated circulating adiponectin levels and fat distribution, i.e. subcutaneous fat area (SFA) and visceral fat area (VFA), in obese subjects. METHODS: Sixty-eight obese Korean subjects underwent fat distribution by computed tomography (CT) scan and laboratory tests including circulating total adiponectin levels (APN) and circulating high molecular weight adiponectin levels (HMW-APN). RESULTS: Log-APN and log-HMW-APN did not correlate with log-BMI either in obese males or females in this study; however, log-APN significantly and negatively correlated with log-VFA both in obese males (r=-0.691, p=0.009) and females (r=-0.319, p=0.002), and log-HMW-APN also correlated negatively with log-VFA both in obese males (r=-0.650, p=0.016) and females (r=-0.370, p=0.005). Log-VFA was a significant determinant of log-APN and log-HMW-APN in obese subjects. In contrast, neither log-APN nor log-HMW-APN was significantly correlated with log-SFA in obese males and females. CONCLUSIONS: The present study demonstrated that APN and HMW-APN correlated with VFA, but not BMI and SFA, in obese subjects, and suggest that hypoadiponectinemia may represent dysfunction of adipose tissue in obesity.
Authors: Karen R Kelly; Sankar D Navaneethan; Thomas P J Solomon; Jacob M Haus; Marc Cook; Hope Barkoukis; John P Kirwan Journal: Med Sci Sports Exerc Date: 2014 Impact factor: 5.411
Authors: W Ma; T Huang; M Wang; Y Zheng; T Wang; Y Heianza; D Sun; S R Smith; G A Bray; F M Sacks; L Qi Journal: Int J Obes (Lond) Date: 2016-07-27 Impact factor: 5.095
Authors: Lauren K Meyer; Theodore P Ciaraldi; Robert R Henry; Alan C Wittgrove; Susan A Phillips Journal: Adipocyte Date: 2013-05-07 Impact factor: 4.534