UNLABELLED: Pathologic fractures of the proximal femur resulting from primary bone sarcomas are often difficult to treat and some are often not recognized resulting in inappropriate interventions prior to the correct diagnosis being made. The aim of the study was to identify factors determining the survival after pathologic fractures of the proximal femur resulting from nonosteogenic primary bone sarcomas. PATIENTS AND METHODS: We retrospectively reviewed 72 patients with nonosteogenic primary bone sarcomas of the proximal femur (chondrosarcoma in 34 patients, spindle cell sarcoma in 25 and Ewing's sarcoma in 13). There were 40 male and 32 female patients. The mean age was 49 years. We analyzed patient, tumor, and treatment factors in relation to overall survival. The mean follow up was 55 months (range 0-302 months). RESULTS: The overall 5-year survival rate was 44% (Ewing's sarcoma 60%, chondrosarcoma 57%, spindle cell sarcoma 30%, and dedifferentiated chondrosarcoma 0%). The diagnosis of spindle cell sarcoma and dedifferentiated chondrosarcoma was the only significant factor adversely affecting survival. There was no difference in survival resulting from timing of the fracture, site of the fracture, age at diagnosis, surgical margin, limb salvage or amputation. CONCLUSIONS: The key-factor adversely affecting the survival after pathologic fractures of the proximal femur resulting from nonosteogenic primary bone sarcomas is the histological diagnosis of dedifferentiated chondrosarcoma and spindle cell sarcoma.
UNLABELLED: Pathologic fractures of the proximal femur resulting from primary bone sarcomas are often difficult to treat and some are often not recognized resulting in inappropriate interventions prior to the correct diagnosis being made. The aim of the study was to identify factors determining the survival after pathologic fractures of the proximal femur resulting from nonosteogenic primary bone sarcomas. PATIENTS AND METHODS: We retrospectively reviewed 72 patients with nonosteogenic primary bone sarcomas of the proximal femur (chondrosarcoma in 34 patients, spindle cell sarcoma in 25 and Ewing's sarcoma in 13). There were 40 male and 32 female patients. The mean age was 49 years. We analyzed patient, tumor, and treatment factors in relation to overall survival. The mean follow up was 55 months (range 0-302 months). RESULTS: The overall 5-year survival rate was 44% (Ewing's sarcoma 60%, chondrosarcoma 57%, spindle cell sarcoma 30%, and dedifferentiated chondrosarcoma 0%). The diagnosis of spindle cell sarcoma and dedifferentiated chondrosarcoma was the only significant factor adversely affecting survival. There was no difference in survival resulting from timing of the fracture, site of the fracture, age at diagnosis, surgical margin, limb salvage or amputation. CONCLUSIONS: The key-factor adversely affecting the survival after pathologic fractures of the proximal femur resulting from nonosteogenic primary bone sarcomas is the histological diagnosis of dedifferentiated chondrosarcoma and spindle cell sarcoma.
Authors: Teresa Calabró; Rupert Van Rooyen; Ilaria Piraino; Elisa Pala; Giulia Trovarelli; Georgios N Panagopoulos; Panayiotis D Megaloikonomos; Andrea Angelini; Andreas F Mavrogenis; Pietro Ruggieri Journal: Eur J Orthop Surg Traumatol Date: 2016-04-04
Authors: Jose I Albergo; Czar L Gaston; Lee M Jeys; Arun Khajuria; Simon R Carter; Roger M Tillman; Adesegun T Abudu; Robert J Grimer Journal: Int Orthop Date: 2015-02-25 Impact factor: 3.075
Authors: Gerhard M Hobusch; Thomas M Tiefenboeck; Janina Patsch; Christoph Krall; Gerold Holzer Journal: Clin Orthop Relat Res Date: 2016-02-16 Impact factor: 4.176