BACKGROUND AND OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) has been a serious problem as its infection is associated with higher mortality and increase cost worldwide. In the present study, the antibacterial activity of enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifolius was investigated. MATERIAL AND METHODS: Enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifolius were tested for antimicrobial activity using micro dilution broth method against 2 strains of ATCC 33591, ATCC 25923 and 15 strains of clinical isolates MRSA. RESULTS: The antibacterial activity of Smallanthus sonchifolius can safely be attributed to enhydrin as polymatin B, and allo-schkuhriolide are not showing any activity against Staphylococcus aureus strains. The enhydrin showed good antibacterial activity against all tested strains (MIC = 125-500 microg/ml). DISCUSSION: These results suggest that only enhydrin can be considered as an antibacterial drug against MRSA.
BACKGROUND AND OBJECTIVES: Methicillin-resistant Staphylococcus aureus (MRSA) has been a serious problem as its infection is associated with higher mortality and increase cost worldwide. In the present study, the antibacterial activity of enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifolius was investigated. MATERIAL AND METHODS: Enhydrin, polymatin B, allo-schkuhriolide from the leaves of Smallanthus sonchifolius were tested for antimicrobial activity using micro dilution broth method against 2 strains of ATCC 33591, ATCC 25923 and 15 strains of clinical isolates MRSA. RESULTS: The antibacterial activity of Smallanthus sonchifolius can safely be attributed to enhydrin as polymatin B, and allo-schkuhriolide are not showing any activity against Staphylococcus aureus strains. The enhydrin showed good antibacterial activity against all tested strains (MIC = 125-500 microg/ml). DISCUSSION: These results suggest that only enhydrin can be considered as an antibacterial drug against MRSA.
Authors: Guillermo F Padilla-González; Evelyn Amrehn; Maximilian Frey; Javier Gómez-Zeledón; Alevtina Kaa; Fernando B Da Costa; Otmar Spring Journal: Int J Mol Sci Date: 2020-06-26 Impact factor: 5.923
Authors: Luis Daniel Goyzueta-Mamani; Haruna Luz Barazorda-Ccahuana; Karel Mena-Ulecia; Miguel Angel Chávez-Fumagalli Journal: Molecules Date: 2021-06-25 Impact factor: 4.411
Authors: F M Frank; J Ulloa; S I Cazorla; G Maravilla; E L Malchiodi; A Grau; V Martino; C Catalán; L V Muschietti Journal: Evid Based Complement Alternat Med Date: 2013-06-06 Impact factor: 2.629