| Literature DB >> 21373965 |
Jintao Qu1, Runmin Yan, Juxiang Chen, Tao Xu, Jingxu Zhou, Mei Wang, Chao Chen, Yong Yan, Yicheng Lu.
Abstract
Gliomas are the most common primary brain tumors in the central nervous system and a leading cause of tumor-related death. High-mobility group nucleosome binding domain 5 (HMGN5/NSBP1), which is highly expressed in breast cancer and in hormone-induced mouse uterine adenocarcinoma, acts as a potential oncogene in gliomas. In this study, the role of HMGN5 in the proliferation of human glioma cells was investigated by lentivirus-mediated RNA interference (RNAi). The decrease in HMGN5 expression in human glioma U251 and U87 cells caused cell cycle arrest in the G1 phase and a delay in cell proliferation, as well as resulting in more apoptosis and an inhibition of clonogenic growth in soft agar in U251 cells; these results suggest that HMGN5 is required for tumorigenesis in vitro. Furthermore, HMGN5 was highly expressed in both high-grade and low-grade glioma tissue samples compared with normal brain tissues. Collectively, our data suggest that HMGN5 may play a critical role in the development of gliomas.Entities:
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Year: 2011 PMID： 21373965 DOI： 10.1007/s11060-011-0558-9
Source DB: PubMed Journal: J Neurooncol ISSN： 0167-594X Impact factor: 4.130