Literature DB >> 19948260

Regulation of chromatin structure and function by HMGN proteins.

Yuri Postnikov1, Michael Bustin.   

Abstract

High mobility group nucleosome-binding (HMGN) proteins are architectural non-histone chromosomal proteins that bind to nucleosomes and modulate the structure and function of chromatin. The interaction of HMGN proteins with nucleosomes is dynamic and the proteins compete with the linker histone H1 chromatin-binding sites. HMGNs reduce the H1-mediated compaction of the chromatin fiber and facilitate the targeting of regulatory factors to chromatin. They modulate the cellular epigenetic profile, affect gene expression and impact the biological processes such as development and the cellular response to environmental and hormonal signals. Here we review the role of HMGN in chromatin structure, the link between HMGN proteins and histone modifications, and discuss the consequence of this link on nuclear processes and cellular phenotype. Published by Elsevier B.V.

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Year:  2009        PMID： 19948260      PMCID： PMC2818575          DOI： 10.1016/j.bbagrm.2009.11.016

Source DB:  PubMed          Journal:  Biochim Biophys Acta        ISSN： 0006-3002


  72 in total

1.  High mobility group protein 17 cross-links primarily to histone H2A in the reconstituted HMG 17-nucleosome core particle complex.

Authors:  G R Cook; P Yau; H Yasuda; R R Traut; E M Bradbury
Journal:  J Biol Chem       Date:  1986-12-05       Impact factor: 5.157

2.  Studies on the conformational properties of the high-mobility-group chromosomal protein HMG 17 and its interaction with DNA.

Authors:  B D Abercrombie; G G Kneale; C Crane-Robinson; E M Bradbury; G H Goodwin; J M Walker; E W Johns
Journal:  Eur J Biochem       Date:  1978-03

3.  Isolation of actively transcribed nucleosomes using immobilized HMG 14 and 17 and an analysis of alpha-globin chromatin.

Authors:  S Weisbrod; H Weintraub
Journal:  Cell       Date:  1981-02       Impact factor: 41.582

4.  The interaction of high mobility proteins HMG14 and 17 with nucleosomes.

Authors:  G Sandeen; W I Wood; G Felsenfeld
Journal:  Nucleic Acids Res       Date:  1980-09-11       Impact factor: 16.971

5.  Interaction of HMG 14 and 17 with actively transcribed genes.

Authors:  S Weisbrod; M Groudine; H Weintraub
Journal:  Cell       Date:  1980-01       Impact factor: 41.582

6.  Nucleosome cores have two specific binding sites for nonhistone chromosomal proteins HMG 14 and HMG 17.

Authors:  J K Mardian; A E Paton; G J Bunick; D E Olins
Journal:  Science       Date:  1980-09-26       Impact factor: 47.728

7.  Distribution of high mobility group proteins 1/2, E and 14/17 and linker histones H1 and H5 on transcribed and non-transcribed regions of chicken erythrocyte chromatin.

Authors:  Y V Postnikov; V V Shick; A V Belyavsky; K R Khrapko; K L Brodolin; T A Nikolskaya; A D Mirzabekov
Journal:  Nucleic Acids Res       Date:  1991-02-25       Impact factor: 16.971

8.  Differentiation-dependent alteration in the chromatin structure of chromosomal protein HMG-17 gene during erythropoiesis.

Authors:  M P Crippa; J M Nickol; M Bustin
Journal:  J Mol Biol       Date:  1991-01-05       Impact factor: 5.469

9.  HMG proteins 14 and 17 become cross-linked to the globular domain of histone H3 near the nucleosome core particle dyad.

Authors:  J V Brawley; H G Martinson
Journal:  Biochemistry       Date:  1992-01-21       Impact factor: 3.162

10.  Binding of HMG14 non-histone protein to histones H2A, H2B, H1 and DNA in reconstituted chromatin.

Authors:  E Espel; J Bernués; J A Pérez-Pons; E Querol
Journal:  Biochem Biophys Res Commun       Date:  1985-11-15       Impact factor: 3.575
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  50 in total

Review 1.  Basic concepts of epigenetics: impact of environmental signals on gene expression.

Authors:  Elizabeth A Mazzio; Karam F A Soliman
Journal:  Epigenetics       Date:  2012-02       Impact factor: 4.528

2.  Genomic profiling of HMGN1 reveals an association with chromatin at regulatory regions.

Authors:  Suresh Cuddapah; Dustin E Schones; Kairong Cui; Tae-Young Roh; Artem Barski; Gang Wei; Mark Rochman; Michael Bustin; Keji Zhao
Journal:  Mol Cell Biol       Date:  2010-12-20       Impact factor: 4.272

3.  The chromatin-binding protein HMGN1 regulates the expression of methyl CpG-binding protein 2 (MECP2) and affects the behavior of mice.

Authors:  Liron Abuhatzira; Alon Shamir; Dustin E Schones; Alejandro A Schäffer; Michael Bustin
Journal:  J Biol Chem       Date:  2011-10-17       Impact factor: 5.157

4.  Distinct properties of human HMGN5 reveal a rapidly evolving but functionally conserved nucleosome binding protein.

Authors:  Cedric Malicet; Mark Rochman; Yuri Postnikov; Michael Bustin
Journal:  Mol Cell Biol       Date:  2011-04-25       Impact factor: 4.272

5.  Elevated HMGN4 expression potentiates thyroid tumorigenesis.

Authors:  Jamie Kugler; Yuri V Postnikov; Takashi Furusawa; Shioko Kimura; Michael Bustin
Journal:  Carcinogenesis       Date:  2017-04-01       Impact factor: 4.944

Review 6.  The role of the nucleosome acidic patch in modulating higher order chromatin structure.

Authors:  Anna A Kalashnikova; Mary E Porter-Goff; Uma M Muthurajan; Karolin Luger; Jeffrey C Hansen
Journal:  J R Soc Interface       Date:  2013-02-27       Impact factor: 4.118

7.  High mobility group N proteins modulate the fidelity of the cellular transcriptional profile in a tissue- and variant-specific manner.

Authors:  Jamie E Kugler; Marion Horsch; Di Huang; Takashi Furusawa; Mark Rochman; Lillian Garrett; Lore Becker; Alexander Bohla; Sabine M Hölter; Cornelia Prehn; Birgit Rathkolb; Ildikó Racz; Juan Antonio Aguilar-Pimentel; Thure Adler; Jerzy Adamski; Johannes Beckers; Dirk H Busch; Oliver Eickelberg; Thomas Klopstock; Markus Ollert; Tobias Stöger; Eckhard Wolf; Wolfgang Wurst; Ali Önder Yildirim; Andreas Zimmer; Valérie Gailus-Durner; Helmut Fuchs; Martin Hrabě de Angelis; Benny Garfinkel; Joseph Orly; Ivan Ovcharenko; Michael Bustin
Journal:  J Biol Chem       Date:  2013-04-24       Impact factor: 5.157

8.  Development of a chemical genetic approach for human aurora B kinase identifies novel substrates of the chromosomal passenger complex.

Authors:  Rutger C C Hengeveld; Nicholas T Hertz; Martijn J M Vromans; Chao Zhang; Alma L Burlingame; Kevan M Shokat; Susanne M A Lens
Journal:  Mol Cell Proteomics       Date:  2012-01-20       Impact factor: 5.911

9.  HMGN1 protein regulates poly(ADP-ribose) polymerase-1 (PARP-1) self-PARylation in mouse fibroblasts.

Authors:  Aya Masaoka; Natalie R Gassman; Padmini S Kedar; Rajendra Prasad; Esther W Hou; Julie K Horton; Michael Bustin; Samuel H Wilson
Journal:  J Biol Chem       Date:  2012-06-26       Impact factor: 5.157

Review 10.  HMGNs, DNA repair and cancer.

Authors:  Gabi Gerlitz
Journal:  Biochim Biophys Acta       Date:  2009-12-08
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