Literature DB >> 21373707

Real-time, in vivo monitoring and pharmacokinetics of valproic acid via a novel biomarker in exhaled breath.

Gerardo Gamez1, Liang Zhu, Andreas Disko, Huanwen Chen, Vladimir Azov, Konstantin Chingin, Günter Krämer, Renato Zenobi.   

Abstract

Extractive electrospray ionization mass spectrometry is shown to allow real-time, in vivo drug monitoring and pharmacokinetic measurement in a non-invasive, pain-free manner as demonstrated by the mass spectral measurement of a novel exhaled breath biomarker for valproic acid, a medication used to control epilepsy. © The Royal Society of Chemistry 2011

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Year:  2011        PMID： 21373707     DOI： 10.1039/c1cc10343a

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  11 in total

1.  Real-time Breath Analysis by Using Secondary Nanoelectrospray Ionization Coupled to High Resolution Mass Spectrometry.

Authors:  Xue Li; Dan D Huang; Rui Du; Zhi J Zhang; Chak K Chan; Zheng X Huang; Zhen Zhou
Journal:  J Vis Exp       Date:  2018-03-09       Impact factor: 1.355

2.  Real-Time Quantitative Analysis of Valproic Acid in Exhaled Breath by Low Temperature Plasma Ionization Mass Spectrometry.

Authors:  Xiaoxia Gong; Songyue Shi; Gerardo Gamez
Journal:  J Am Soc Mass Spectrom       Date:  2016-11-09       Impact factor: 3.109

3.  Personalised therapeutic management of epileptic patients guided by pathway-driven breath metabolomics.

Authors:  Alexandre N Datta; Pablo Sinues; Kapil Dev Singh; Martin Osswald; Victoria C Ziesenitz; Mo Awchi; Jakob Usemann; Lukas L Imbach; Malcolm Kohler; Diego García-Gómez; Johannes van den Anker; Urs Frey
Journal:  Commun Med (Lond)       Date:  2021-08-02

4.  Enabling quantitative analysis in ambient ionization mass spectrometry: internal standard coated capillary samplers.

Authors:  Jiangjiang Liu; R Graham Cooks; Zheng Ouyang
Journal:  Anal Chem       Date:  2013-06-05       Impact factor: 6.986

5.  Two different approaches for pharmacokinetic modeling of exhaled drug concentrations.

Authors:  S Kreuer; A Hauschild; T Fink; J I Baumbach; S Maddula; Th Volk
Journal:  Sci Rep       Date:  2014-06-24       Impact factor: 4.379

Review 6.  The expanding role of electrospray ionization mass spectrometry for probing reactive intermediates in solution.

Authors:  Weitao Zhu; Yu Yuan; Peng Zhou; Le Zeng; Hua Wang; Ling Tang; Bin Guo; Bo Chen
Journal:  Molecules       Date:  2012-09-27       Impact factor: 4.411

7.  Reactive Laser Ablation Electrospray Ionization Time-Resolved Mass Spectrometry of Click Reactions.

Authors:  Fred A M G van Geenen; Maurice C R Franssen; Han Zuilhof; Michel W F Nielen
Journal:  Anal Chem       Date:  2018-08-13       Impact factor: 6.986

8.  Human breath analysis may support the existence of individual metabolic phenotypes.

Authors:  Pablo Martinez-Lozano Sinues; Malcolm Kohler; Renato Zenobi
Journal:  PLoS One       Date:  2013-04-03       Impact factor: 3.240

9.  Facilitated diffusion of acetonitrile revealed by quantitative breath analysis using extractive electrospray ionization mass spectrometry.

Authors:  Ming Li; Jianhua Ding; Haiwei Gu; Yan Zhang; Susu Pan; Ning Xu; Huanwen Chen; Hongmei Li
Journal:  Sci Rep       Date:  2013-02-05       Impact factor: 4.379

10.  Direct characterization of bulk samples by internal extractive electrospray ionization mass spectrometry.

Authors:  Hua Zhang; Haiwei Gu; Feiyan Yan; Nannan Wang; Yiping Wei; Jianjun Xu; Huanwen Chen
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379
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