OBJECTIVE: Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS: Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p<0.001. Morphological analyses showed a high prevalence of osteoid metaplasia in femoral arteries (63%) compared to carotid arteries (20%, p<0.001). Biochemical analyses were consistent with histological data, showing higher calcium and lesser cholesterol concentrations in femoral than in carotid plaques (p<0.01). CONCLUSIONS: Femoral and carotid plaques showed different morphology in comparable groups of patients.
OBJECTIVE: Results of endovascular repair vary according to the arterial bed. We hypothesized that these differences may be related to the plaque features. To explore this hypothesis, we designed a prospective study that compared carotid and femoral atheroma. METHODS AND RESULTS:Patients that underwent femoral or carotid endarterectomy were included in our study. Demographic data and blood sampling were obtained prior to surgery. Plaques were evaluated for AHA grading, calcification and lipid content. Eighty-eight plaques were harvested during this study (45 carotid specimens and 43 femoral specimens). No differences were noted between carotid and femoral groups regarding demographic and biological data. Histological data more frequently showed fibrous cap atheroma in carotid arteries (75%) and fibrocalcific plaques in femoral arteries (93%), p<0.001. Morphological analyses showed a high prevalence of osteoid metaplasia in femoral arteries (63%) compared to carotid arteries (20%, p<0.001). Biochemical analyses were consistent with histological data, showing higher calcium and lesser cholesterol concentrations in femoral than in carotid plaques (p<0.01). CONCLUSIONS: Femoral and carotid plaques showed different morphology in comparable groups of patients.
Authors: Valvanera Fernández-Laso; Cristina Sastre; Jose M Valdivielso; Angels Betriu; Elvira Fernández; Jesús Egido; Jose L Martín-Ventura; Luis M Blanco-Colio Journal: Clin J Am Soc Nephrol Date: 2016-01-04 Impact factor: 8.237
Authors: Elizabeth Salisbury; John Hipp; Elizabeth A Olmsted-Davis; Alan R Davis; Michael H Heggeness; Francis H Gannon Journal: Hum Pathol Date: 2012-06-27 Impact factor: 3.466
Authors: Mircea Catalin Cosarca; Emőke Horváth; Calin Molnar; Gyopár-Beáta Molnár; Eliza Russu; Vasile Adrian Mureșan Journal: Exp Ther Med Date: 2021-06-11 Impact factor: 2.447
Authors: Francesco Vasuri; Sabrina Valente; Ilenia Motta; Alessio Degiovanni; Carmen Ciavarella; Gianandrea Pasquinelli Journal: Front Cell Dev Biol Date: 2021-06-16
Authors: Athanasios D Protogerou; Jaap Fransen; Evangelia Zampeli; Antonis A Argyris; Evagelia Aissopou; Aikaterini Arida; George D Konstantonis; Nikos Tentolouris; Konstantinos Makrilakis; Mina Psichogiou; George Daikos; George D Kitas; Petros P Sfikakis Journal: PLoS One Date: 2015-07-31 Impact factor: 3.240