Literature DB >> 2136253

Albendazole: a more effective antigiardial agent in vitro than metronidazole or tinidazole.

B P Meloni1, R C Thompson, J A Reynoldson, P Seville.   

Abstract

The effects of albendazole were assessed against Giardia duodenalis in vitro and compared with those of tinidazole and metronidazole. Trophozoite morphology, adherence and viability were markedly affected by albendazole, to a far greater extent than by either metronidazole or tinidazole. The results of this study, and in particular the superior potency of albendazole in vitro, are discussed with respect to its potential value as a new approach to the chemotherapy of giardiasis.

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Year:  1990        PMID: 2136253     DOI: 10.1016/0035-9203(90)90324-8

Source DB:  PubMed          Journal:  Trans R Soc Trop Med Hyg        ISSN: 0035-9203            Impact factor:   2.184


  16 in total

1.  In vivo efficacy of albendazole against Giardia duodenalis in mice.

Authors:  J A Reynoldson; R C Thompson; B P Meloni
Journal:  Parasitol Res       Date:  1991       Impact factor: 2.289

Review 2.  Treatment of giardiasis.

Authors:  T B Gardner; D R Hill
Journal:  Clin Microbiol Rev       Date:  2001-01       Impact factor: 26.132

3.  Heterogeneity in the sensitivity of microtubules of Giardia lamblia to the herbicide oryzalin.

Authors:  Letícia L Terra; Loraine Campanati; Wanderley De Souza
Journal:  Parasitol Res       Date:  2010-04-20       Impact factor: 2.289

4.  Structure-activity studies of dicationically substituted bis-benzimidazoles against Giardia lamblia: correlation of antigiardial activity with DNA binding affinity and giardial topoisomerase II inhibition.

Authors:  C A Bell; C C Dykstra; N A Naiman; M Cory; T A Fairley; R R Tidwell
Journal:  Antimicrob Agents Chemother       Date:  1993-12       Impact factor: 5.191

5.  Activities of several benzimidazoles and tubulin inhibitors against Giardia spp. in vitro.

Authors:  U M Morgan; J A Reynoldson; R C Thompson
Journal:  Antimicrob Agents Chemother       Date:  1993-02       Impact factor: 5.191

Review 6.  The biology of Giardia spp.

Authors:  R D Adam
Journal:  Microbiol Rev       Date:  1991-12

7.  A randomised multicentre study to compare the safety and efficacy of albendazole and metronidazole in the treatment of giardiasis in children.

Authors:  A K Dutta; M A Phadke; A C Bagade; V Joshi; A Gazder; T K Biswas; H H Gill; S C Jagota
Journal:  Indian J Pediatr       Date:  1994 Nov-Dec       Impact factor: 1.967

8.  Antiprotozoal activities of benzimidazoles and correlations with beta-tubulin sequence.

Authors:  S K Katiyar; V R Gordon; G L McLaughlin; T D Edlind
Journal:  Antimicrob Agents Chemother       Date:  1994-09       Impact factor: 5.191

9.  Albendazole chemotherapy for treatment of diarrhoea in patients with AIDS in Zambia: a randomised double blind controlled trial.

Authors:  P Kelly; F Lungu; E Keane; R Baggaley; F Kazembe; J Pobee; M Farthing
Journal:  BMJ       Date:  1996-05-11

10.  Flowcytometric assessment of the effect of drugs on Giardia lamblia trophozoites in vitro.

Authors:  Harpreet Sandhu; Ramesh Chander Mahajan; Nirmal Kumar Ganguly
Journal:  Mol Cell Biochem       Date:  2004-10       Impact factor: 3.396

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