| Literature DB >> 21359495 |
Yong Lu1, Feng Jiang, Xuguang Zheng, Mark Katakowski, Benjamin Buller, Shing-Shun Tony To, Michael Chopp.
Abstract
The transforming growth factor β1 (TGF-β1) belongs to a family of structurally related polypeptide factors. TGF-beta plays an important role in the pathobiology of invasion of malignant gliomas. The objective of the present study was to investigate the impact of TNF-α converting enzyme (TACE/ADAM17) signaling on the process of TGF-β1-stimulated migration and invasion of T98G glioma cells. We found that TGF-β1 increased migration and invasiveness in glioma cells. Addition of the TGF-β1 receptor inhibitor, SB431542, reduced the TGF-β1-stimulated migration and invasiveness of glioma cells. In addition, TGF-β1-induced migration and invasiveness were also blocked by exposure to an ADAM17 inhibitor, TAPI-2. Furthermore, ADAM17 mRNA and protein expression were up-regulated by TGF-β1. Treatment with SB431542 and TAPI-2 blocked TGF-β1-induced ADAM17 protein expression. In summary, these results indicate that TGF-β1 promotes cell migration and invasiveness of glioma cells through stimulation of ADAM17.Entities:
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Year: 2011 PMID： 21359495 PMCID： PMC3070292 DOI： 10.3892/or.2011.1195
Source DB: PubMed Journal: Oncol Rep ISSN： 1021-335X Impact factor: 3.906