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Literature DB >> 23017135

Negative regulation of myeloid-derived suppressor cells in cancer.

Peng Qu¹, Kimberly C Boelte, P Charles Lin.

Abstract

Myeloid-derived suppressor cells (MDSC) are a heterogeneous population of immature myeloid cells with suppressive function on immune response. In this review, we discuss recent studies about mechanisms of expansion and suppressive function of MDSCs during inflammation, infection and autoimmune diseases, as well as pro-angiogenic and pro-metastatic functions of these cells in tumor development. Further, we focus on novel studies of MDSCs and therapeutic approaches to eliminate these cells in cancer.

Entities: Chemical Disease Gene Species

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Year: 2012 PMID： 23017135 PMCID： PMC7469827 DOI： 10.3109/08820139.2012.685538

Source DB: PubMed Journal: Immunol Invest ISSN： 0882-0139 Impact factor: 3.657

107 in total

1. NF-kappaB dysregulation in microRNA-146a-deficient mice drives the development of myeloid malignancies.

Authors: Jimmy L Zhao; Dinesh S Rao; Mark P Boldin; Konstantin D Taganov; Ryan M O'Connell; David Baltimore
Journal: Proc Natl Acad Sci U S A Date: 2011-05-16 Impact factor: 11.205

Review 2. Myeloid derived suppressor cells in human diseases.

Authors: Tim F Greten; Michael P Manns; Firouzeh Korangy
Journal: Int Immunopharmacol Date: 2011-01-13 Impact factor: 4.932

3. Gr-1+CD115+ immature myeloid suppressor cells mediate the development of tumor-induced T regulatory cells and T-cell anergy in tumor-bearing host.

Authors: Bo Huang; Ping-Ying Pan; Qingsheng Li; Alice I Sato; David E Levy; Jonathan Bromberg; Celia M Divino; Shu-Hsia Chen
Journal: Cancer Res Date: 2006-01-15 Impact factor: 12.701

4. Myeloid-specific expression of human lysosomal acid lipase corrects malformation and malfunction of myeloid-derived suppressor cells in lal-/- mice.

Authors: Peng Qu; Cong Yan; Janice S Blum; Reuben Kapur; Hong Du
Journal: J Immunol Date: 2011-09-07 Impact factor: 5.422

5. COX-2 blockade suppresses gliomagenesis by inhibiting myeloid-derived suppressor cells.

Authors: Mitsugu Fujita; Gary Kohanbash; Wendy Fellows-Mayle; Ronald L Hamilton; Yoshihiro Komohara; Stacy A Decker; John R Ohlfest; Hideho Okada
Journal: Cancer Res Date: 2011-02-15 Impact factor: 12.701

Review 6. Derangement of immune responses by myeloid suppressor cells.

Authors: Paolo Serafini; Carmela De Santo; Ilaria Marigo; Sara Cingarlini; Luigi Dolcetti; Giovanna Gallina; Paola Zanovello; Vincenzo Bronte
Journal: Cancer Immunol Immunother Date: 2003-10-30 Impact factor: 6.968

7. Prostaglandin E2 promotes tumor progression by inducing myeloid-derived suppressor cells.

Authors: Pratima Sinha; Virginia K Clements; Amy M Fulton; Suzanne Ostrand-Rosenberg
Journal: Cancer Res Date: 2007-05-01 Impact factor: 12.701

8. Reduced inflammation in the tumor microenvironment delays the accumulation of myeloid-derived suppressor cells and limits tumor progression.

Authors: Stephanie K Bunt; Linglin Yang; Pratima Sinha; Virginia K Clements; Jeff Leips; Suzanne Ostrand-Rosenberg
Journal: Cancer Res Date: 2007-10-15 Impact factor: 12.701

9. Endotoxin-induced myeloid-derived suppressor cells inhibit alloimmune responses via heme oxygenase-1.

Authors: V De Wilde; N Van Rompaey; M Hill; J F Lebrun; P Lemaître; F Lhommé; C Kubjak; B Vokaer; G Oldenhove; L M Charbonnier; M C Cuturi; M Goldman; A Le Moine
Journal: Am J Transplant Date: 2009-07-22 Impact factor: 8.086

10. MyD88-dependent expansion of an immature GR-1(+)CD11b(+) population induces T cell suppression and Th2 polarization in sepsis.

Authors: Matthew J Delano; Philip O Scumpia; Jason S Weinstein; Dominique Coco; Srinivas Nagaraj; Kindra M Kelly-Scumpia; Kerri A O'Malley; James L Wynn; Svetlana Antonenko; Samer Z Al-Quran; Ryan Swan; Chun-Shiang Chung; Mark A Atkinson; Reuben Ramphal; Dmitry I Gabrilovich; Wesley H Reeves; Alfred Ayala; Joseph Phillips; Drake Laface; Paul G Heyworth; Michael Clare-Salzler; Lyle L Moldawer
Journal: J Exp Med Date: 2007-06-04 Impact factor: 14.307

13 in total

Review 1. Expansion and functions of myeloid-derived suppressor cells in the tumor microenvironment.

Authors: Peng Qu; Li-Zhen Wang; P Charles Lin
Journal: Cancer Lett Date: 2015-10-28 Impact factor: 8.679

2. The significant increase and dynamic changes of the myeloid-derived suppressor cells percentage with chemotherapy in advanced NSCLC patients.

Authors: S Wang; Y Fu; K Ma; C Liu; X Jiao; W Du; H Zhang; X Wu
Journal: Clin Transl Oncol Date: 2013-11-06 Impact factor: 3.405

Review 3. Myeloid-derived suppressor cells: the dark knight or the joker in viral infections?

Authors: Celeste Goh; Sowmya Narayanan; Young S Hahn
Journal: Immunol Rev Date: 2013-09 Impact factor: 12.988

4. Deficiency of Kruppel-like factor KLF4 in myeloid-derived suppressor cells inhibits tumor pulmonary metastasis in mice accompanied by decreased fibrocytes.

Authors: Y Shi; L Ou; S Han; M Li; M M O Pena; E A Pena; C Liu; M Nagarkatti; D Fan; W Ai
Journal: Oncogenesis Date: 2014-11-24 Impact factor: 7.485

Review 5. MicroRNA networks regulate the differentiation, expansion and suppression function of myeloid-derived suppressor cells in tumor microenvironment.

Authors: Yanping Su; Ye Qiu; Zhidong Qiu; Peng Qu
Journal: J Cancer Date: 2019-07-10 Impact factor: 4.207

Review 6. Reactive Oxygen Species in the Tumor Microenvironment: An Overview.

Authors: Frank Weinberg; Nithya Ramnath; Deepak Nagrath
Journal: Cancers (Basel) Date: 2019-08-16 Impact factor: 6.639

7. Increased levels of granulocytic myeloid-derived suppressor cells in peripheral blood and tumour tissue of pancreatic cancer patients.

Authors: Yazan S Khaled; Basil J Ammori; Eyad Elkord
Journal: J Immunol Res Date: 2014-01-29 Impact factor: 4.818