BACKGROUND AND AIMS: Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions. METHODS: Multi-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry. RESULTS: We show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters. CONCLUSION: The phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection.
BACKGROUND AND AIMS: Helicobacter pylori colonises the stomach in half of all humans, and is the principal cause of gastric cancer, the second leading cause of cancer death worldwide. While gastric cancer rates correlate with H pylori prevalence in some areas, there are regions where infection is nearly universal, but rates of gastric cancer are low. In the case of Colombia, there is a 25-fold increase in gastric cancer rate in the Andean mountain (high risk) region compared to the coastal (low risk) region, despite similarly high (∼90%) prevalence of H pylori in the two locations. Our aim was to investigate the ancestral origin of H pylori strains isolated from subjects in these high- and low-risk regions and to determine whether this is a predictive determinant of precancerous lesions. METHODS: Multi-locus sequence typing was used to investigate phylogeographic origins of infecting H pylori strains isolated from subjects in the Pacific coast and Andes Mountains in the state of Nariño, Colombia. We analysed 64 subjects infected with cagA+ vacA s1m1 strains. Gastric biopsy slides from each individual were scored for histological lesions and evaluated for DNA damage by immunohistochemistry. RESULTS: We show that strains from the high-risk region were all of European phylogeographic origin, whereas those from the low risk region were of either European (34%) or African origin (66%). European strain origin was strongly predictive of increased premalignant histological lesions and epithelial DNA damage, even in the low-risk region; African strain origin was associated with reduced severity of these parameters. CONCLUSION: The phylogeographic origin of H pylori strains provides an explanation for geographic differences in cancer risk deriving from this infection.
Authors: P Correa; J Fox; E Fontham; B Ruiz; Y P Lin; D Zavala; N Taylor; D Mackinley; E de Lima; H Portilla Journal: Cancer Date: 1990-12-15 Impact factor: 6.860
Authors: M I Filipe; N Muñoz; I Matko; I Kato; V Pompe-Kirn; A Jutersek; S Teuchmann; M Benz; T Prijon Journal: Int J Cancer Date: 1994-05-01 Impact factor: 7.396
Authors: M Rugge; P Correa; F Di Mario; E El-Omar; R Fiocca; K Geboes; R M Genta; D Y Graham; T Hattori; P Malfertheiner; S Nakajima; P Sipponen; J Sung; W Weinstein; M Vieth Journal: Dig Liver Dis Date: 2008-08 Impact factor: 4.088
Authors: Daniela Basso; Carlo-Federico Zambon; Darren P Letley; Alessia Stranges; Alberto Marchet; Joanne L Rhead; Stefania Schiavon; Graziella Guariso; Marco Ceroti; Donato Nitti; Massimo Rugge; Mario Plebani; John C Atherton Journal: Gastroenterology Date: 2008-03-25 Impact factor: 22.682
Authors: M Blanca Piazuelo; M Constanza Camargo; Robertino M Mera; Alberto G Delgado; Richard M Peek; Hernan Correa; Barbara G Schneider; Liviu A Sicinschi; Yolanda Mora; Luis E Bravo; Pelayo Correa Journal: Hum Pathol Date: 2008-07-09 Impact factor: 3.466
Authors: Michael Y Esmail; Rebecca Bacon; Alton G Swennes; Yan Feng; Zeli Shen; AnaPatricia Garcia; Prachi Sharma; Joyce Cohen; James G Fox Journal: Helicobacter Date: 2015-10-19 Impact factor: 5.753
Authors: Meira Epplein; Michael Pawlita; Angelika Michel; Richard M Peek; Qiuyin Cai; William J Blot Journal: Cancer Epidemiol Biomarkers Prev Date: 2013-09-17 Impact factor: 4.254
Authors: Javier Torres; Pelayo Correa; Catterina Ferreccio; Gustavo Hernandez-Suarez; Rolando Herrero; Maria Cavazza-Porro; Ricardo Dominguez; Douglas Morgan Journal: Cancer Causes Control Date: 2012-12-07 Impact factor: 2.506
Authors: Patricia Bonequi; Fernando Meneses-González; Pelayo Correa; Charles S Rabkin; M Constanza Camargo Journal: Cancer Causes Control Date: 2012-12-07 Impact factor: 2.506
Authors: Jennifer M Noto; Kristie L Rose; Amanda J Hachey; Alberto G Delgado; Judith Romero-Gallo; Lydia E Wroblewski; Barbara G Schneider; Shailja C Shah; Timothy L Cover; Keith T Wilson; Dawn A Israel; Juan Carlos Roa; Kevin L Schey; Yana Zavros; M Blanca Piazuelo; Richard M Peek Journal: Mol Cell Proteomics Date: 2018-11-19 Impact factor: 5.911