OBJECTIVES: To evaluate the prevalence of HRCT findings in construction workers previously surveyed by chest radiographs classified according to ILO guidelines. To examine the association between HRCT findings and exposure to quartz containing dust, and lung function. METHODS: The study comprised a questionnaire, dynamic and static lung function measurements, single-breath CO diffusion capacity, chest radiographs and HRCT in 79 individuals. Certified 'B' readers coded radiographs according to the ILO classification. HRCT scans were read according to an international classification system. A qualitative exposure index for cumulative respiratory quartz on a 10-point scale was used. RESULTS: Agreement between HRCT readers was good (κ>0.60), except for irregular opacities (κ=0.23). In ILO category 0/0, 8% HRCT round, 22% irregular and/or linear opacities and 41% HRCT emphysema was found. HRCT round opacities was associated with high cumulative quartz exposure (OR 7.1; 95% CI 1.3 to 37.8). Emphysema was associated with smoking (OR 10.1; 95% CI 1.2 to 84.2) and showed a reduction in T(L,CO,sb). HRCT round opacities was not associated with lung function. Current smoking was negatively associated with FEV₁/FVC ratio and positively with RV/TLC ratio, and showed a reduction in T(L,CO,sb) (13.4%), adjusted for different HRCT findings. CONCLUSIONS: Low grade silicosis cannot be excluded in workers with normal chest radiographs (ILO 0/0). In relatively highly exposed construction workers, a sevenfold increased risk of simple (nodular) silicosis was found. Emphysema on HRCT was associated with current or former smokers, but not with exposure, and contributed to reduced diffusion capacity. Airflow limitation was mainly determined by current smoking and was not associated with simple (nodular) silicosis.
OBJECTIVES: To evaluate the prevalence of HRCT findings in construction workers previously surveyed by chest radiographs classified according to ILO guidelines. To examine the association between HRCT findings and exposure to quartz containing dust, and lung function. METHODS: The study comprised a questionnaire, dynamic and static lung function measurements, single-breath CO diffusion capacity, chest radiographs and HRCT in 79 individuals. Certified 'B' readers coded radiographs according to the ILO classification. HRCT scans were read according to an international classification system. A qualitative exposure index for cumulative respiratory quartz on a 10-point scale was used. RESULTS: Agreement between HRCT readers was good (κ>0.60), except for irregular opacities (κ=0.23). In ILO category 0/0, 8% HRCT round, 22% irregular and/or linear opacities and 41% HRCT emphysema was found. HRCT round opacities was associated with high cumulative quartz exposure (OR 7.1; 95% CI 1.3 to 37.8). Emphysema was associated with smoking (OR 10.1; 95% CI 1.2 to 84.2) and showed a reduction in T(L,CO,sb). HRCT round opacities was not associated with lung function. Current smoking was negatively associated with FEV₁/FVC ratio and positively with RV/TLC ratio, and showed a reduction in T(L,CO,sb) (13.4%), adjusted for different HRCT findings. CONCLUSIONS: Low grade silicosis cannot be excluded in workers with normal chest radiographs (ILO 0/0). In relatively highly exposed construction workers, a sevenfold increased risk of simple (nodular) silicosis was found. Emphysema on HRCT was associated with current or former smokers, but not with exposure, and contributed to reduced diffusion capacity. Airflow limitation was mainly determined by current smoking and was not associated with simple (nodular) silicosis.
Authors: Nathaniel Marchetti; Eric Garshick; Gregory L Kinney; Alex McKenzie; Douglas Stinson; Sharon M Lutz; David A Lynch; Gerard J Criner; Edwin K Silverman; James D Crapo Journal: Am J Respir Crit Care Med Date: 2014-10-01 Impact factor: 21.405
Authors: Marek A Mikulski; Alicia K Gerke; John D Newell; Ann M Murray; Carmen J Smith; Laurence J Fuortes Journal: Int J Occup Environ Health Date: 2016-05-04
Authors: Dario Consonni; Sara De Matteis; Angela C Pesatori; Pier Alberto Bertazzi; Ann C Olsson; Hans Kromhout; Susan Peters; Roel C H Vermeulen; Beate Pesch; Thomas Brüning; Benjamin Kendzia; Thomas Behrens; Isabelle Stücker; Florence Guida; Heinz-Erich Wichmann; Irene Brüske; Maria Teresa Landi; Neil E Caporaso; Per Gustavsson; Nils Plato; Lap Ah Tse; Ignatius Tak-Sun Yu; Karl-Heinz Jöckel; Wolfgang Ahrens; Hermann Pohlabeln; Franco Merletti; Lorenzo Richiardi; Lorenzo Simonato; Francesco Forastiere; Jack Siemiatycki; Marie-Élise Parent; Adonina Tardón; Paolo Boffetta; David Zaridze; Ying Chen; John K Field; Andrea 't Mannetje; Neil Pearce; John McLaughlin; Paul Demers; Jolanta Lissowska; Neonila Szeszenia-Dabrowska; Vladimir Bencko; Lenka Foretova; Vladimir Janout; Peter Rudnai; Eleonóra Fabiánová; Rodica Stanescu Dumitru; H Bas Bueno-de-Mesquita; Joachim Schüz; Kurt Straif Journal: Int J Cancer Date: 2014-06-03 Impact factor: 7.396
Authors: Taewoo Kim; Hyun Bin Cho; Woo Jin Kim; Chang Hyun Lee; Kum Ju Chae; So-Hyun Choi; Kyeong Eun Lee; So Hyeon Bak; Sung Ok Kwon; Gong Yong Jin; Jiwoong Choi; Eun-Kee Park; Ching-Long Lin; Eric A Hoffman; Sanghun Choi Journal: Respir Res Date: 2020-05-29