| Literature DB >> 21354459 |
Allison R Baker1, Sarah Zalwango, LaShaunda L Malone, Robert P Igo, Feiyou Qiu, Mary Nsereko, Mark D Adams, Pamela Supelak, Harriet Mayanja-Kizza, W Henry Boom, Catherine M Stein.
Abstract
Tuberculosis (TB), caused by Mycobacterium tuberculosis (Mtb), causes 9 million new cases worldwide and 2 million deaths annually. Genetic linkage and association analyses have suggested several chromosomal regions and candidate genes involved in TB susceptibility. This study examines the association of TB disease susceptibility with a selection of biologically relevant genes on regions on chromosomes 7 (IL6 and CARD11) and 20 (CTSZ and MC3R) and fine mapping of the chromosome 7p22-p21 region identified through our genome scan. We analyzed 565 individuals from Kampala, Uganda, who were previously included in our genome-wide linkage scan. Association analyses were conducted for 1,417 single-nucleotide polymorphisms (SNP) that passed quality control. None of the candidate gene or fine mapping SNPs was significantly associated with TB susceptibility (p > 0.10). When we restricted the analysis to HIV-negative individuals, 2 SNPs on chromosome 7 were significantly associated with TB susceptibility (p < 0.05). Haplotype analyses identified a significant risk haplotype in cathepsin X (CTSZ; p = 0.0281, odds ratio = 1.5493, 95% confidence interval [1.039, 2.320]).Entities:
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Year: 2011 PMID： 21354459 PMCID： PMC3078986 DOI： 10.1016/j.humimm.2011.02.016
Source DB: PubMed Journal: Hum Immunol ISSN： 0198-8859 Impact factor: 2.850