Literature DB >> 21353593

27-Hydroxycholesterol: the first identified endogenous SERM.

Michihisa Umetani1, Philip W Shaul.   

Abstract

The cholesterol metabolite 27-hydroxycholesterol (27OHC) classically delivers sterols from peripheral tissues to the liver and is a substrate for bile acid synthesis. Recent studies have revealed that 27OHC also binds to and modifies the function of estrogen receptors ERα and ERβ. Experiments in mice lacking the enzyme which synthesizes 27OHC, CYP27A1, or the enzyme which catabolizes 27OHC, CYP7B1, have demonstrated that 27OHC adversely affects estrogen-related cardiovascular protection and bone mineralization. Work in breast cancer cells further indicates that 27OHC alters ER target gene expression to promote cell growth. Therefore, 27OHC is the first identified endogenous selective estrogen receptor modulator (SERM) and could have an important impact upon the cardiovascular system, bone biology, and cancer.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21353593      PMCID： PMC3070823          DOI： 10.1016/j.tem.2011.01.003

Source DB:  PubMed          Journal:  Trends Endocrinol Metab        ISSN： 1043-2760            Impact factor:   12.015


  48 in total

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  35 in total

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