PURPOSE: To evaluate the use of semi-quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters for the detection of prostatic carcinoma in correlation to whole-mount histopathology. MATERIALS AND METHODS: Fifty-three patients with biopsy-proven prostate cancer were examined by DCE-MRI at 1.5-T. Cancerous and benign prostatic tissue regions of interest were delineated based on the histopathology of whole-mount sections and several semi-quantitative parameters were calculated: time to peak (TTP), maximal contrast enhancement (Cpeak), speed of contrast uptake (Wash-in) and clearance rate of the contrast agent (Wash-out). The area under the ROC curve was determined for each parameter. RESULTS: Within individual patients, a consistently higher Cpeak and faster Wash-in were present in cancerous compared to benign prostatic tissue. Both the TTP and the Wash-out occurred more rapidly in tumour tissue than in normal prostatic tissue. Despite a considerable inter-patient overlap of parameter values between tumour and normal prostatic tissue, area under the ROC curve analysis demonstrated that the Wash-in was a good discriminator for cancer and benign tissue (AUC 0.82). Combination of the Wash-in and the Wash-out proved to be even more accurate (AUC 0.87) to discriminate between cancerous and benign prostatic regions. CONCLUSION: The Wash-in is a useful parameter for prostate cancer detection by DCE-MRI.
PURPOSE: To evaluate the use of semi-quantitative dynamic contrast-enhanced MRI (DCE-MRI) parameters for the detection of prostatic carcinoma in correlation to whole-mount histopathology. MATERIALS AND METHODS: Fifty-three patients with biopsy-proven prostate cancer were examined by DCE-MRI at 1.5-T. Cancerous and benign prostatic tissue regions of interest were delineated based on the histopathology of whole-mount sections and several semi-quantitative parameters were calculated: time to peak (TTP), maximal contrast enhancement (Cpeak), speed of contrast uptake (Wash-in) and clearance rate of the contrast agent (Wash-out). The area under the ROC curve was determined for each parameter. RESULTS: Within individual patients, a consistently higher Cpeak and faster Wash-in were present in cancerous compared to benign prostatic tissue. Both the TTP and the Wash-out occurred more rapidly in tumour tissue than in normal prostatic tissue. Despite a considerable inter-patient overlap of parameter values between tumour and normal prostatic tissue, area under the ROC curve analysis demonstrated that the Wash-in was a good discriminator for cancer and benign tissue (AUC 0.82). Combination of the Wash-in and the Wash-out proved to be even more accurate (AUC 0.87) to discriminate between cancerous and benign prostatic regions. CONCLUSION: The Wash-in is a useful parameter for prostate cancer detection by DCE-MRI.
Authors: Otilia C Nasui; Michael W Chan; George Nathanael; Adrian Crawley; Elka Miller; Jaques Belik; Hai-Ling Cheng; Andrea Kassner; Tammy Rayner; Ruth Weiss; Garry Detzler; Anguo Zhong; Rahim Moineddin; Roland Jong; Marianne Rogers; Andrea S Doria Journal: Eur Radiol Date: 2014-09-04 Impact factor: 5.315
Authors: Andrew B Rosenkrantz; Christian Geppert; Robert Grimm; Tobias K Block; Christian Glielmi; Li Feng; Ricardo Otazo; Justin M Ream; Melanie Moccaldi Romolo; Samir S Taneja; Daniel K Sodickson; Hersh Chandarana Journal: J Magn Reson Imaging Date: 2014-05-16 Impact factor: 4.813
Authors: Nestor Andres Parra; Alan Pollack; Felix M Chinea; Matthew C Abramowitz; Brian Marples; Felipe Munera; Rosa Castillo; Oleksandr N Kryvenko; Sanoj Punnen; Radka Stoyanova Journal: Front Oncol Date: 2017-11-10 Impact factor: 6.244