Literature DB >> 21344104

Natural withanolides: an overview.

Li-Xia Chen1, Hao He, Feng Qiu.   

Abstract

Withanolides are a group of naturally occurring C28 steroids built on an ergostane skeleton functionalized at carbons 1, 22 and 26, commonly known as the withanolide skeleton. Over the period of August 1996 to March 2010, 360 new naturally occurring withanolides were isolated and identified. This review provides a comprehensive summary of the structural classification and distribution of these new compounds. The diverse biological and pharmacological activities of natural withanolides are also discussed based on their structural features. A total of 211 references are cited in this review.

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Year:  2011        PMID： 21344104     DOI： 10.1039/c0np00045k

Source DB:  PubMed          Journal:  Nat Prod Rep        ISSN： 0265-0568            Impact factor:   13.423


  60 in total

1.  Withanolides from Aeroponically Grown Physalis peruviana and Their Selective Cytotoxicity to Prostate Cancer and Renal Carcinoma Cells.

Authors:  Ya-Ming Xu; E M Kithsiri Wijeratne; Ashley L Babyak; Hanna R Marks; Alan D Brooks; Poonam Tewary; Li-Jiang Xuan; Wen-Qiong Wang; Thomas J Sayers; A A Leslie Gunatilaka
Journal:  J Nat Prod       Date:  2017-06-15       Impact factor: 4.050

Review 2.  Recent trends in the structural revision of natural products.

Authors:  Bhuwan Khatri Chhetri; Serge Lavoie; Anne Marie Sweeney-Jones; Julia Kubanek
Journal:  Nat Prod Rep       Date:  2018-06-20       Impact factor: 13.423

3.  Ectopic overexpression of WsSGTL1, a sterol glucosyltransferase gene in Withania somnifera, promotes growth, enhances glycowithanolide and provides tolerance to abiotic and biotic stresses.

Authors:  Syed Saema; Laiq Ur Rahman; Ruchi Singh; Abhishek Niranjan; Iffat Zareen Ahmad; Pratibha Misra
Journal:  Plant Cell Rep       Date:  2015-10-30       Impact factor: 4.570

4.  New withanolides with TRAIL-sensitizing effect from Physalis pubescens L.

Authors:  Li-Xia Chen; Gui-Yang Xia; Hao He; Jian Huang; Feng Qiu; Xiao-Lin Zi
Journal:  RSC Adv       Date:  2016-05-26       Impact factor: 3.361

5.  Stereo- and region-specific biotransformation of physapubescin by four fungal strains.

Authors:  Chongyue Qiu; Ting Yuan; Dejuan Sun; Suyu Gao; Lixia Chen
Journal:  J Nat Med       Date:  2017-01-10       Impact factor: 2.343

6.  WsSGTL1 gene from Withania somnifera, modulates glycosylation profile, antioxidant system and confers biotic and salt stress tolerance in transgenic tobacco.

Authors:  Vibha Pandey; Abhishek Niranjan; Neelam Atri; K Chandrashekhar; Manoj K Mishra; Prabodh K Trivedi; Pratibha Misra
Journal:  Planta       Date:  2014-03-08       Impact factor: 4.116

7.  The genetic architecture of ecological adaptation: intraspecific variation in host plant use by the lepidopteran crop pest Chloridea virescens.

Authors:  Sara J Oppenheim; Fred Gould; Keith R Hopper
Journal:  Heredity (Edinb)       Date:  2017-12-14       Impact factor: 3.821

8.  Minor withanolides of Physalis longifolia: structure and cytotoxicity.

Authors:  Huaping Zhang; Hashim Motiwala; Abbas Samadi; Victor Day; Jeffrey Aubé; Mark Cohen; Kelly Kindscher; Rao Gollapudi; Barbara Timmermann
Journal:  Chem Pharm Bull (Tokyo)       Date:  2012       Impact factor: 1.645

9.  Antiproliferative withanolides from Datura wrightii.

Authors:  Huaping Zhang; Joseph Bazzill; Robert J Gallagher; Chitra Subramanian; Patrick T Grogan; Victor W Day; Kelly Kindscher; Mark S Cohen; Barbara N Timmermann
Journal:  J Nat Prod       Date:  2012-12-19       Impact factor: 4.050

10.  Comprehensive assessment of the genes involved in withanolide biosynthesis from Withania somnifera: chemotype-specific and elicitor-responsive expression.

Authors:  Aditya Vikram Agarwal; Parul Gupta; Deeksha Singh; Yogeshwar Vikram Dhar; Deepak Chandra; Prabodh Kumar Trivedi
Journal:  Funct Integr Genomics       Date:  2017-03-11       Impact factor: 3.410
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