OBJECTIVE: Medical radiation exposure has increased sixfold since 1980 and is the largest controllable source of exposure. Many efforts have been devoted to reducing dose or eliminating unnecessary examinations but with limited success. The concern regarding nuclear terrorism has focused a large amount of attention on radioprotective drugs. The purpose of this article is twofold: to review the current concepts, potential, and limitations of chemical radioprotectants in reducing stochastic and deterministic effects and to assess the potential application to diagnostic and interventional medical radiation procedures. CONCLUSION: There are a wide variety of chemical compounds that have been studied for radioprotective effects. Although there is promising research, chemical radioprotectants have not been shown to be very effective and, with one limited exception, are not the standard of care in medicine.
OBJECTIVE: Medical radiation exposure has increased sixfold since 1980 and is the largest controllable source of exposure. Many efforts have been devoted to reducing dose or eliminating unnecessary examinations but with limited success. The concern regarding nuclear terrorism has focused a large amount of attention on radioprotective drugs. The purpose of this article is twofold: to review the current concepts, potential, and limitations of chemical radioprotectants in reducing stochastic and deterministic effects and to assess the potential application to diagnostic and interventional medical radiation procedures. CONCLUSION: There are a wide variety of chemical compounds that have been studied for radioprotective effects. Although there is promising research, chemical radioprotectants have not been shown to be very effective and, with one limited exception, are not the standard of care in medicine.
Authors: Stephen S Yoo; Timothy J Jorgensen; Ann R Kennedy; John D Boice; Alla Shapiro; Tom C-C Hu; Brian R Moyer; Marcy B Grace; Gary J Kelloff; Michael Fenech; Pataje G S Prasanna; C Norman Coleman Journal: J Radiol Prot Date: 2014-04-14 Impact factor: 1.394
Authors: Rajat Chauhan; Kelsey Kinney; Archana Akalkotkar; Betty M Nunn; Robert S Keynton; Patricia A Soucy; Martin G O'Toole Journal: RSC Adv Date: 2020-04-23 Impact factor: 4.036
Authors: Franco Cortese; Dmitry Klokov; Andreyan Osipov; Jakub Stefaniak; Alexey Moskalev; Jane Schastnaya; Charles Cantor; Alexander Aliper; Polina Mamoshina; Igor Ushakov; Alex Sapetsky; Quentin Vanhaelen; Irina Alchinova; Mikhail Karganov; Olga Kovalchuk; Ruth Wilkins; Andrey Shtemberg; Marjan Moreels; Sarah Baatout; Evgeny Izumchenko; João Pedro de Magalhães; Artem V Artemov; Sylvain V Costes; Afshin Beheshti; Xiao Wen Mao; Michael J Pecaut; Dmitry Kaminskiy; Ivan V Ozerov; Morten Scheibye-Knudsen; Alex Zhavoronkov Journal: Oncotarget Date: 2018-02-12