Literature DB >> 21343466

In vitro activity of Proveblue (methylene blue) on Plasmodium falciparum strains resistant to standard antimalarial drugs.

Aurélie Pascual1, Maud Henry, Sébastien Briolant, Serge Charras, Eric Baret, Rémy Amalvict, Emilie Huyghues des Etages, Michel Feraud, Christophe Rogier, Bruno Pradines.   

Abstract

The geometric mean 50% inhibitory concentration (IC50) for Proveblue, a methylene blue complying with the European Pharmacopoeia, was more active on 23 P. falciparum strains than chloroquine, quinine, mefloquine, monodesethylamodiaquine, and lumefantrine. We did not find significant associations between the Proveblue IC50 and polymorphisms in the pfcrt, pfmdr1, pfmdr2, pfmrp, and pfnhe-1 genes or the copy numbers of the pfmdr1 and pfmdr2 genes, all of which are involved in antimalarial resistance.

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Year:  2011        PMID： 21343466      PMCID： PMC3088279          DOI： 10.1128/AAC.01466-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

1.  Synergy of mefloquine activity with atorvastatin, but not chloroquine and monodesethylamodiaquine, and association with the pfmdr1 gene.

Authors:  Nathalie Wurtz; Sébastien Briolant; Marine Gil; Véronique Parquet; Maud Henry; Eric Baret; Rémy Amalvict; Lionel Almeras; Christophe Rogier; Bruno Pradines
Journal:  J Antimicrob Chemother       Date:  2010-05-25       Impact factor: 5.790

2.  Selection of Plasmodium falciparum pfmdr1 alleles following therapy with artemether-lumefantrine in an area of Uganda where malaria is highly endemic.

Authors:  Christian Dokomajilar; Samuel L Nsobya; Bryan Greenhouse; Philip J Rosenthal; Grant Dorsey
Journal:  Antimicrob Agents Chemother       Date:  2006-05       Impact factor: 5.191

3.  In vitro assessment of methylene blue on chloroquine-sensitive and -resistant Plasmodium falciparum strains reveals synergistic action with artemisinins.

Authors:  Monique Akoachere; Kathrin Buchholz; Elisabeth Fischer; Jürgen Burhenne; Walter E Haefeli; R Heiner Schirmer; Katja Becker
Journal:  Antimicrob Agents Chemother       Date:  2005-11       Impact factor: 5.191

4.  Safety of the combination of chloroquine and methylene blue in healthy adult men with G6PD deficiency from rural Burkina Faso.

Authors:  Germain Mandi; Steffen Witte; Peter Meissner; Boubacar Coulibaly; Ulrich Mansmann; Jens Rengelshausen; Wolfgang Schiek; Albrecht Jahn; Mamadou Sanon; Kirsten Wüst; Ingeborg Walter-Sack; Gerd Mikus; Jürgen Burhenne; Klaus-Dieter Riedel; Heiner Schirmer; Bocar Kouyaté; Olaf Müller
Journal:  Trop Med Int Health       Date:  2005-01       Impact factor: 2.622

5.  Genetic diversity and structure of African Plasmodium falciparum populations in urban and rural areas.

Authors:  Hervé Bogreau; François Renaud; Housem Bouchiba; Patrick Durand; Serge-Brice Assi; Marie-Claire Henry; Eric Garnotel; Bruno Pradines; Thierry Fusai; Boubacar Wade; Eric Adehossi; Philippe Parola; Mohamed Ali Kamil; Odile Puijalon; Christophe Rogier
Journal:  Am J Trop Med Hyg       Date:  2006-06       Impact factor: 2.345

6.  Dissecting the loci of low-level quinine resistance in malaria parasites.

Authors:  Michael T Ferdig; Roland A Cooper; Jianbing Mu; Bingbing Deng; Deirdre A Joy; Xin-zhuan Su; Thomas E Wellems
Journal:  Mol Microbiol       Date:  2004-05       Impact factor: 3.501

7.  Quinoline resistance associated polymorphisms in the pfcrt, pfmdr1 and pfmrp genes of Plasmodium falciparum in Iran.

Authors:  J Ursing; S Zakeri; J P Gil; A Björkman
Journal:  Acta Trop       Date:  2006-02-20       Impact factor: 3.112

8.  Antimalarial dyes revisited: xanthenes, azines, oxazines, and thiazines.

Authors:  J L Vennerstrom; M T Makler; C K Angerhofer; J A Williams
Journal:  Antimicrob Agents Chemother       Date:  1995-12       Impact factor: 5.191

9.  Mode of antimalarial effect of methylene blue and some of its analogues on Plasmodium falciparum in culture and their inhibition of P. vinckei petteri and P. yoelii nigeriensis in vivo.

Authors:  H Atamna; M Krugliak; G Shalmiev; E Deharo; G Pescarmona; H Ginsburg
Journal:  Biochem Pharmacol       Date:  1996-03-08       Impact factor: 5.858

10.  Safety of the methylene blue plus chloroquine combination in the treatment of uncomplicated falciparum malaria in young children of Burkina Faso [ISRCTN27290841].

Authors:  Peter E Meissner; Germain Mandi; Steffen Witte; Boubacar Coulibaly; Ulrich Mansmann; Jens Rengelshausen; Wolfgang Schiek; Albrecht Jahn; Mamadou Sanon; Théophile Tapsoba; Ingeborg Walter-Sack; Gerd Mikus; Jürgen Burhenne; Klaus-Dieter Riedel; Heiner Schirmer; Bocar Kouyaté; Olaf Müller
Journal:  Malar J       Date:  2005-09-22       Impact factor: 2.979
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  20 in total

1.  Quantitative assessment of Plasmodium falciparum sexual development reveals potent transmission-blocking activity by methylene blue.

Authors:  Sophie H Adjalley; Geoffrey L Johnston; Tao Li; Richard T Eastman; Eric H Ekland; Abraham G Eappen; Adam Richman; B Kim Lee Sim; Marcus C S Lee; Stephen L Hoffman; David A Fidock
Journal:  Proc Natl Acad Sci U S A       Date:  2011-10-31       Impact factor: 11.205

2.  Baseline in vitro activities of the antimalarials pyronaridine and methylene blue against Plasmodium falciparum isolates from Kenya.

Authors:  John Okombo; Steven M Kiara; Leah Mwai; Lewa Pole; Eric Ohuma; Lynette Isabella Ochola; Alexis Nzila
Journal:  Antimicrob Agents Chemother       Date:  2011-11-28       Impact factor: 5.191

3.  Proveblue (methylene blue) as an antimalarial agent: in vitro synergy with dihydroartemisinin and atorvastatin.

Authors:  Jérôme Dormoi; Aurélie Pascual; Sébastien Briolant; Rémy Amalvict; Serge Charras; Eric Baret; Emilie Huyghues des Etages; Michel Feraud; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2012-03-05       Impact factor: 5.191

4.  Dose responses of proveblue methylene blue in an experimental murine cerebral malaria model.

Authors:  Jérome Dormoi; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2013-05-13       Impact factor: 5.191

5.  Male and female Plasmodium falciparum mature gametocytes show different responses to antimalarial drugs.

Authors:  Michael J Delves; Andrea Ruecker; Ursula Straschil; Jöel Lelièvre; Sara Marques; María José López-Barragán; Esperanza Herreros; Robert E Sinden
Journal:  Antimicrob Agents Chemother       Date:  2013-04-29       Impact factor: 5.191

6.  Potent Ex Vivo Activity of Naphthoquine and Methylene Blue against Drug-Resistant Clinical Isolates of Plasmodium falciparum and Plasmodium vivax.

Authors:  Grennady Wirjanata; Boni F Sebayang; Ferryanto Chalfein; Irene Handayuni; Leily Trianty; Enny Kenangalem; Rintis Noviyanti; Brice Campo; Jeanne Rini Poespoprodjo; Jörg J Möhrle; Ric N Price; Jutta Marfurt
Journal:  Antimicrob Agents Chemother       Date:  2015-07-20       Impact factor: 5.191

7.  Efficacy of proveblue (methylene blue) in an experimental cerebral malaria murine model.

Authors:  Jérome Dormoi; Sébastien Briolant; Camille Desgrouas; Bruno Pradines
Journal:  Antimicrob Agents Chemother       Date:  2013-04-22       Impact factor: 5.191

8.  Artemisone and Artemiside Are Potent Panreactive Antimalarial Agents That Also Synergize Redox Imbalance in Plasmodium falciparum Transmissible Gametocyte Stages.

Authors:  Dina Coertzen; Janette Reader; Mariëtte van der Watt; Sindisiwe H Nondaba; Liezl Gibhard; Lubbe Wiesner; Peter Smith; Sarah D'Alessandro; Donatella Taramelli; Ho Ning Wong; Jan L du Preez; Ronald Wai Keung Wu; Lyn-Marie Birkholtz; Richard K Haynes
Journal:  Antimicrob Agents Chemother       Date:  2018-07-27       Impact factor: 5.191

Review 9.  Methylene blue and its analogues as antidepressant compounds.

Authors:  Anzelle Delport; Brian H Harvey; Anél Petzer; Jacobus P Petzer
Journal:  Metab Brain Dis       Date:  2017-07-31       Impact factor: 3.584

10.  Pharmacokinetics and Ex Vivo Antimalarial Activity of Artesunate-Amodiaquine plus Methylene Blue in Healthy Volunteers.

Authors:  Chu Xuan Anh; Marina Chavchich; Geoffrey W Birrell; Karin Van Breda; Thomas Travers; Kerryn Rowcliffe; Anton R Lord; G Dennis Shanks; Michael D Edstein
Journal:  Antimicrob Agents Chemother       Date:  2020-02-21       Impact factor: 5.191
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