Literature DB >> 21343449

In vitro activities of synthetic host defense propeptides processed by neutrophil elastase against cystic fibrosis pathogens.

Stephane Desgranges1, Florie Le Prieult, Alan Daly, Jennifer Lydon, Marian Brennan, Dilip K Rai, Anusha P Subasinghage, Chandralal M Hewage, Sally-Ann Cryan, Catherine Greene, Noel G McElvaney, Timothy P Smyth, Deirdre Fitzgerald-Hughes, Hilary Humphreys, Marc Devocelle.   

Abstract

The antimicrobial and hemolytic activities of a host defense peptide can be controlled by its modification as a propeptide of reduced net charge, which can then be processed by neutrophil elastase, a serine protease involved in chronic airway inflammation and infections associated with cystic fibrosis.

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Year:  2011        PMID： 21343449      PMCID： PMC3088215          DOI： 10.1128/AAC.01384-10

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  26 in total

Review 1.  Amphipathic, alpha-helical antimicrobial peptides.

Authors:  A Tossi; L Sandri; A Giangaspero
Journal:  Biopolymers       Date:  2000       Impact factor: 2.505

2.  Antimicrobial peptides of multicellular organisms.

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Journal:  Nature       Date:  2002-01-24       Impact factor: 49.962

Review 3.  Cationic peptides: effectors in innate immunity and novel antimicrobials.

Authors:  R E Hancock
Journal:  Lancet Infect Dis       Date:  2001-10       Impact factor: 25.071

Review 4.  Can innate immunity be enhanced to treat microbial infections?

Authors:  B Brett Finlay; Robert E W Hancock
Journal:  Nat Rev Microbiol       Date:  2004-06       Impact factor: 60.633

Review 5.  Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.

Authors:  W Bode; E Meyer; J C Powers
Journal:  Biochemistry       Date:  1989-03-07       Impact factor: 3.162

6.  Synthetic magainin analogues with improved antimicrobial activity.

Authors:  H C Chen; J H Brown; J L Morell; C M Huang
Journal:  FEBS Lett       Date:  1988-08-29       Impact factor: 4.124

7.  Solid phase synthesis.

Authors:  B Merrifield
Journal:  Science       Date:  1986-04-18       Impact factor: 47.728

8.  Salt resistance and synergistic effect with vancomycin of alpha-helical antimicrobial peptide P18.

Authors:  Song Yub Shin; Sung-Tae Yang; Eun Ju Park; Soo Hyun Eom; Woo Keun Song; Yangmee Kim; Kyung-Soo Hahm; Jae Il Kim
Journal:  Biochem Biophys Res Commun       Date:  2002-01-11       Impact factor: 3.575

9.  LL-37 complexation with glycosaminoglycans in cystic fibrosis lungs inhibits antimicrobial activity, which can be restored by hypertonic saline.

Authors:  Gudmundur Bergsson; Emer P Reeves; Paul McNally; Sanjay H Chotirmall; Catherine M Greene; Peter Greally; Philip Murphy; Shane J O'Neill; Noel G McElvaney
Journal:  J Immunol       Date:  2009-07-01       Impact factor: 5.422

10.  Kinetics of proteolysis of hog gastric mucin by human neutrophil elastase and by Pseudomonas aeruginosa elastase.

Authors:  L Poncz; N Jentoft; M C Ho; D G Dearborn
Journal:  Infect Immun       Date:  1988-03       Impact factor: 3.441
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  8 in total

Review 1.  Modifications of natural peptides for nanoparticle and drug design.

Authors:  Andrew P Jallouk; Rohun U Palekar; Hua Pan; Paul H Schlesinger; Samuel A Wickline
Journal:  Adv Protein Chem Struct Biol       Date:  2015-03-12       Impact factor: 3.507

2.  Influence of Proline Substitution on the Bioactivity of Mammalian-Derived Antimicrobial Peptide NK-2.

Authors:  Jiexi Yan; Xiaolei Liang; Chang Liu; Yuemei Cheng; Lanxia Zhou; Kairong Wang; Li Zhao
Journal:  Probiotics Antimicrob Proteins       Date:  2018-03       Impact factor: 4.609

3.  Delivery of a Protease-Activated Cytolytic Peptide Prodrug by Perfluorocarbon Nanoparticles.

Authors:  Andrew P Jallouk; Rohun U Palekar; Jon N Marsh; Hua Pan; Christine T N Pham; Paul H Schlesinger; Samuel A Wickline
Journal:  Bioconjug Chem       Date:  2015-07-02       Impact factor: 4.774

4.  Potential of host defense peptide prodrugs as neutrophil elastase-dependent anti-infective agents for cystic fibrosis.

Authors:  Eanna Forde; Hilary Humphreys; Catherine M Greene; Deirdre Fitzgerald-Hughes; Marc Devocelle
Journal:  Antimicrob Agents Chemother       Date:  2013-11-25       Impact factor: 5.191

Review 5.  Current treatments for biofilm-associated periprosthetic joint infection and new potential strategies.

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Journal:  J Orthop Res       Date:  2022-05-06       Impact factor: 3.102

6.  Targeted antimicrobial peptides.

Authors:  Marc Devocelle
Journal:  Front Immunol       Date:  2012-10-05       Impact factor: 7.561

7.  PEGylated Oligothioetheramide Prodrugs Activated by Host Serum Proteases.

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Journal:  Chembiochem       Date:  2021-07-13       Impact factor: 3.461

8.  Characterization of Antimicrobial Peptides toward the Development of Novel Antibiotics.

Authors:  Wataru Aoki; Mitsuyoshi Ueda
Journal:  Pharmaceuticals (Basel)       Date:  2013-08-21
  8 in total

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