Literature DB >> 21341790

Chiral calcium VAPOL phosphate mediated asymmetric chlorination and Michael reactions of 3-substituted oxindoles.

Wenhua Zheng1, Zuhui Zhang, Matthew J Kaplan, Jon C Antilla.   

Abstract

We disclose a novel high yielding and highly enantioselective chiral calcium VAPOL phosphate-catalyzed chlorination of 3-substituted oxindoles with N-chlorosuccinimide (NCS). The reaction conditions are also shown to be effective for the catalytic enantioselective Michael addition of 3-aryloxindoles to methyl vinyl ketone.

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Year:  2011        PMID： 21341790      PMCID： PMC3103939          DOI： 10.1021/ja109824x

Source DB:  PubMed          Journal:  J Am Chem Soc        ISSN： 0002-7863            Impact factor:   15.419


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