| Literature DB >> 21341715 |
Carmen Festa1, Simona De Marino, Valentina Sepe, Maria Valeria D'Auria, Giuseppe Bifulco, Cecile Débitus, Mariarosaria Bucci, Valentina Vellecco, Angela Zampella.
Abstract
Two unprecedented cyclic peptides, solomonamides A and B, were isolated from the marine sponge Theonella swinhoei. The structures were elucidated on the basis of comprehensive 1D and 2D NMR analysis and high-resolution mass spectrometry. A combined approach, involving Marfey's method, QM J based analysis, and DFT J/(13)C calculations, was used for establishing the absolute configuration of the entire molecule. Solomonamide A showed in vivo anti-inflammatory activity.Entities:
Mesh:
Substances:
Year: 2011 PMID: 21341715 DOI: 10.1021/ol200221n
Source DB: PubMed Journal: Org Lett ISSN: 1523-7052 Impact factor: 6.005