INTRODUCTION: Chemotherapy-induced nausea and vomiting (CINV) is one of the most important worries of cancer patients. Although not life-threatening, it has a great negative impact on quality of life (QOL). OBJECTIVE: The aim of this study was to determine the impact of CINV (i.e., acute and delayed) on breast cancer patients QOL and to discern opinions related with antiemetic guidelines used dependent on the three main races in Malaysia (Malay, Chinese, Indian). METHODS: In this longitudinal prospective observational study, 158 breast cancer patients treated with chemotherapy were interviewed and valid questionnaires (MANE and ONEM) were used to report the impact of CINV on their QOL within the first 24 hours and after 3 to 5 days of chemotherapy treatment. RESULTS: The main result was that delayed CINV has an impact on QOL greater than acute CINV. The impact of nausea was reportedly higher than that of vomiting. Also differences in race i.e., genetic polymorphisms (pharmacogenomics) influenced the utility of antiemetic treatments and patients opinions. CONCLUSION: Based on the results of our study a new guideline for antiemetic treatment should be used to reduce the impact of CINV on QOL, taking into account variation in genetic polymorphisms among the three races in Malaysia.
INTRODUCTION: Chemotherapy-induced nausea and vomiting (CINV) is one of the most important worries of cancerpatients. Although not life-threatening, it has a great negative impact on quality of life (QOL). OBJECTIVE: The aim of this study was to determine the impact of CINV (i.e., acute and delayed) on breast cancerpatients QOL and to discern opinions related with antiemetic guidelines used dependent on the three main races in Malaysia (Malay, Chinese, Indian). METHODS: In this longitudinal prospective observational study, 158 breast cancerpatients treated with chemotherapy were interviewed and valid questionnaires (MANE and ONEM) were used to report the impact of CINV on their QOL within the first 24 hours and after 3 to 5 days of chemotherapy treatment. RESULTS: The main result was that delayed CINV has an impact on QOL greater than acute CINV. The impact of nausea was reportedly higher than that of vomiting. Also differences in race i.e., genetic polymorphisms (pharmacogenomics) influenced the utility of antiemetic treatments and patients opinions. CONCLUSION: Based on the results of our study a new guideline for antiemetic treatment should be used to reduce the impact of CINV on QOL, taking into account variation in genetic polymorphisms among the three races in Malaysia.
Authors: Dorothy M K Keefe; Alexandre Chan; Hoon-Kyo Kim; Ruey Kuen Hsieh; Shiying Yu; Yachuan Wang; Rebecca J Nicholls; Thomas A Burke Journal: Support Care Cancer Date: 2014-08-13 Impact factor: 3.603
Authors: Alexandre Chan; Matin M Abdullah; Wan Zamaniah B Wan Ishak; Annielyn B Ong-Cornel; Antonio H Villalon; Ravindran Kanesvaran Journal: J Glob Oncol Date: 2016-11-09