PURPOSE: Cerebral palsy (CP) with a prevalence of 2.1 per 1,000 live births generates variable degrees of incurable developmental disability. The aim of the present report was to provide insight in the safety and feasibility of autologous umbilical cord blood (UCB) transfusion with low dose Granulocyte Colony Stimulating Factor (G-CSF) injections in improving the functional outcome of children with cerebral palsy. METHODS: Two toddlers with diagnosed CP were given autologous umbilical cord blood (UCB) transfusion accompanied by low dose subcutaneous granulocyte colony stimulating factor (G-CSF) injections. RESULTS: Gross Motor Function Classification System (GMFCS) improvements were seen in both without any side effects being noted to date. CONCLUSION: In this first report, autologous UCB based intervention in tandem with low dose sc G-CSF administration seems to be feasible and safe with encouraging functional outcome improvements in children with CP.
PURPOSE:Cerebral palsy (CP) with a prevalence of 2.1 per 1,000 live births generates variable degrees of incurable developmental disability. The aim of the present report was to provide insight in the safety and feasibility of autologous umbilical cord blood (UCB) transfusion with low dose Granulocyte Colony Stimulating Factor (G-CSF) injections in improving the functional outcome of children with cerebral palsy. METHODS: Two toddlers with diagnosed CP were given autologous umbilical cord blood (UCB) transfusion accompanied by low dose subcutaneous granulocyte colony stimulating factor (G-CSF) injections. RESULTS: Gross Motor Function Classification System (GMFCS) improvements were seen in both without any side effects being noted to date. CONCLUSION: In this first report, autologous UCB based intervention in tandem with low dose sc G-CSF administration seems to be feasible and safe with encouraging functional outcome improvements in children with CP.
Authors: C Michael Cotten; Amy P Murtha; Ronald N Goldberg; Chad A Grotegut; P Brian Smith; Ricki F Goldstein; Kimberley A Fisher; Kathryn E Gustafson; Barbara Waters-Pick; Geeta K Swamy; Benjamin Rattray; Siddhartha Tan; Joanne Kurtzberg Journal: J Pediatr Date: 2013-12-31 Impact factor: 4.406
Authors: Kyunghoon Min; Junyoung Song; Jin Young Kang; Jooyeon Ko; Ju Seok Ryu; Myung Seo Kang; Su Jin Jang; Sang Heum Kim; Doyeun Oh; Moon Kyu Kim; Sung Soo Kim; Minyoung Kim Journal: Stem Cells Date: 2013-03 Impact factor: 6.277