Kumkum Jha1, Mridula Shukla, Manoj Pandey. 1. Department of Surgical Oncology, Institute of Medical Sciences, Banaras Hindu University, Varanasi, India.
Abstract
INTRODUCTION: Survivin a multifunctional protein that controls cell division, inhibition of apoptosis and promotion of angiogenesis. It is expressed in most human neoplasm, but is absent in normal and differentiated tissues. The purpose of this article is to overview the expression of survivin, effect of its expression in response to treatment, correlation with other markers and newer advancement in targeting survivin. METHODS: A detailed search of Medline was carried out using the following search strategy: "((survivin) OR ((apoptosis) AND (inhibitor OR inhibitors))) AND ((breast) AND (neoplasm OR neoplasms OR tumor OR tumor OR cancer OR carcinoma))". Abstract of all articles thus identified were reviewed to identify the relevant studies, full articles of studies thus identified were then obtained and reviewed. All relevant data was extracted and tabulated. RESULTS: Survivin expression by Immunohistochemistry was identified in 65.3% (55.2-90.0%) of the breast cancer patients among the identified studies while survivin mRNA by RT-PCR was identified in 93.6% (90-97%). Survivin expression has been reported to be associated with over expression of HER 2, vascular endothelial growth factor (VEGF), urokinase plasminogen activator (uPA)/PAI-1. CONCLUSION: Survivin is over expressed in majority of breast cancers. The over expression of survivin is found to correlate with HER 2 and EGFR expression. Survivin expression has been found to confer resistance to chemotherapy and radiation. Targeting survivin in experimental models improves survival. More studies are needed on the role of survivin in multi drug resistance (MDR) in the presence of Pgp/uPA/PAI-1 and the impact of survivin over expression in triple negative breast cancer.
INTRODUCTION: Survivin a multifunctional protein that controls cell division, inhibition of apoptosis and promotion of angiogenesis. It is expressed in most humanneoplasm, but is absent in normal and differentiated tissues. The purpose of this article is to overview the expression of survivin, effect of its expression in response to treatment, correlation with other markers and newer advancement in targeting survivin. METHODS: A detailed search of Medline was carried out using the following search strategy: "((survivin) OR ((apoptosis) AND (inhibitor OR inhibitors))) AND ((breast) AND (neoplasm OR neoplasms OR tumor OR tumor OR cancer OR carcinoma))". Abstract of all articles thus identified were reviewed to identify the relevant studies, full articles of studies thus identified were then obtained and reviewed. All relevant data was extracted and tabulated. RESULTS: Survivin expression by Immunohistochemistry was identified in 65.3% (55.2-90.0%) of the breast cancerpatients among the identified studies while survivin mRNA by RT-PCR was identified in 93.6% (90-97%). Survivin expression has been reported to be associated with over expression of HER 2, vascular endothelial growth factor (VEGF), urokinase plasminogen activator (uPA)/PAI-1. CONCLUSION: Survivin is over expressed in majority of breast cancers. The over expression of survivin is found to correlate with HER 2 and EGFR expression. Survivin expression has been found to confer resistance to chemotherapy and radiation. Targeting survivin in experimental models improves survival. More studies are needed on the role of survivin in multi drug resistance (MDR) in the presence of Pgp/uPA/PAI-1 and the impact of survivin over expression in triple negative breast cancer.
Authors: Xu Wang; Jonathan J Beitler; Wen Huang; Guo Chen; Guoqing Qian; Kelly Magliocca; Mihir R Patel; Amy Y Chen; Jun Zhang; Sreenivas Nannapaneni; Sungjin Kim; Zhengjia Chen; Xingming Deng; Nabil F Saba; Zhuo Georgia Chen; Jack L Arbiser; Dong M Shin Journal: Clin Cancer Res Date: 2017-11-27 Impact factor: 12.531
Authors: Maria Kabisch; Justo Lorenzo Bermejo; Thomas Dünnebier; Shibo Ying; Kyriaki Michailidou; Manjeet K Bolla; Qin Wang; Joe Dennis; Mitul Shah; Barbara J Perkins; Kamila Czene; Hatef Darabi; Mikael Eriksson; Stig E Bojesen; Børge G Nordestgaard; Sune F Nielsen; Henrik Flyger; Diether Lambrechts; Patrick Neven; Stephanie Peeters; Caroline Weltens; Fergus J Couch; Janet E Olson; Xianshu Wang; Kristen Purrington; Jenny Chang-Claude; Anja Rudolph; Petra Seibold; Dieter Flesch-Janys; Julian Peto; Isabel dos-Santos-Silva; Nichola Johnson; Olivia Fletcher; Heli Nevanlinna; Taru A Muranen; Kristiina Aittomäki; Carl Blomqvist; Marjanka K Schmidt; Annegien Broeks; Sten Cornelissen; Frans B L Hogervorst; Jingmei Li; Judith S Brand; Keith Humphreys; Pascal Guénel; Thérèse Truong; Florence Menegaux; Marie Sanchez; Barbara Burwinkel; Frederik Marmé; Rongxi Yang; Peter Bugert; Anna González-Neira; Javier Benitez; M Pilar Zamora; Jose I Arias Perez; Angela Cox; Simon S Cross; Malcolm W R Reed; Irene L Andrulis; Julia A Knight; Gord Glendon; Sandrine Tchatchou; Elinor J Sawyer; Ian Tomlinson; Michael J Kerin; Nicola Miller; Christopher A Haiman; Fredrick Schumacher; Brian E Henderson; Loic Le Marchand; Annika Lindblom; Sara Margolin; Maartje J Hooning; Antoinette Hollestelle; Mieke Kriege; Linetta B Koppert; John L Hopper; Melissa C Southey; Helen Tsimiklis; Carmel Apicella; Seth Slettedahl; Amanda E Toland; Celine Vachon; Drakoulis Yannoukakos; Graham G Giles; Roger L Milne; Catriona McLean; Peter A Fasching; Matthias Ruebner; Arif B Ekici; Matthias W Beckmann; Hermann Brenner; Aida K Dieffenbach; Volker Arndt; Christa Stegmaier; Alan Ashworth; Nicholas Orr; Minouk J Schoemaker; Anthony Swerdlow; Montserrat García-Closas; Jonine Figueroa; Stephen J Chanock; Jolanta Lissowska; Mark S Goldberg; France Labrèche; Martine Dumont; Robert Winqvist; Katri Pylkäs; Arja Jukkola-Vuorinen; Mervi Grip; Hiltrud Brauch; Thomas Brüning; Yon-Dschun Ko; Paolo Radice; Paolo Peterlongo; Giulietta Scuvera; Stefano Fortuzzi; Natalia Bogdanova; Thilo Dörk; Arto Mannermaa; Vesa Kataja; Veli-Matti Kosma; Jaana M Hartikainen; Peter Devilee; Robert A E M Tollenaar; Caroline Seynaeve; Christi J Van Asperen; Anna Jakubowska; Jan Lubinski; Katarzyna Jaworska-Bieniek; Katarzyna Durda; Wei Zheng; Martha J Shrubsole; Qiuyin Cai; Diana Torres; Hoda Anton-Culver; Vessela Kristensen; François Bacot; Daniel C Tessier; Daniel Vincent; Craig Luccarini; Caroline Baynes; Shahana Ahmed; Mel Maranian; Jacques Simard; Georgia Chenevix-Trench; Per Hall; Paul D P Pharoah; Alison M Dunning; Douglas F Easton; Ute Hamann Journal: Carcinogenesis Date: 2015-01-13 Impact factor: 4.944