Literature DB >> 21334249

Regulation of hepatocyte fate by interferon-γ.

Christopher J Horras1, Cheri L Lamb, Kristen A Mitchell.   

Abstract

Interferon (IFN)-γ is a cytokine known for its immunomodulatory and anti-proliferative action. In the liver, IFN-γ can induce hepatocyte apoptosis or inhibit hepatocyte cell cycle progression. This article reviews recent mechanistic reports that describe how IFN-γ may direct the fate of hepatocytes either towards apoptosis or a cell cycle arrest. This review also describes a probable role for IFN-γ in modulating hepatocyte fate during liver regeneration, transplantation, hepatitis, fibrosis and hepatocellular carcinoma, and highlights promising areas of research that may lead to the development of IFN-γ as a therapy to enhance recovery from liver disease.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21334249      PMCID： PMC3068863          DOI： 10.1016/j.cytogfr.2011.01.001

Source DB:  PubMed          Journal:  Cytokine Growth Factor Rev        ISSN： 1359-6101            Impact factor:   7.638


  143 in total

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Journal:  Z Gastroenterol       Date:  2006-01       Impact factor: 2.000

2.  Activation-induced cell death of hepatic stellate cells by the innate immune system.

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Journal:  Gastroenterology       Date:  2006-02       Impact factor: 22.682

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Journal:  J Immunol       Date:  1999-12-15       Impact factor: 5.422

5.  STAT1 inhibits liver fibrosis in mice by inhibiting stellate cell proliferation and stimulating NK cell cytotoxicity.

Authors:  Won-Il Jeong; Ogyi Park; Svetlana Radaeva; Bin Gao
Journal:  Hepatology       Date:  2006-12       Impact factor: 17.425

6.  IFITM1 plays an essential role in the antiproliferative action of interferon-gamma.

Authors:  G Yang; Y Xu; X Chen; G Hu
Journal:  Oncogene       Date:  2006-07-17       Impact factor: 9.867

7.  Abrogation of the antifibrotic effects of natural killer cells/interferon-gamma contributes to alcohol acceleration of liver fibrosis.

Authors:  Won-Il Jeong; Ogyi Park; Bin Gao
Journal:  Gastroenterology       Date:  2007-09-29       Impact factor: 22.682

Review 8.  The molecular cell biology of interferon-gamma and its receptor.

Authors:  M A Farrar; R D Schreiber
Journal:  Annu Rev Immunol       Date:  1993       Impact factor: 28.527

9.  Protective effect of hepatocyte growth factor on interferon-gamma-induced cytotoxicity in mouse hepatocytes.

Authors:  M Morita; Y Watanabe; T Akaike
Journal:  Hepatology       Date:  1995-06       Impact factor: 17.425

10.  Impairment of liver regeneration correlates with activated hepatic NKT cells in HBV transgenic mice.

Authors:  Zhongjun Dong; Jianhong Zhang; Rui Sun; Haiming Wei; Zhigang Tian
Journal:  Hepatology       Date:  2007-06       Impact factor: 17.425
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  47 in total

1.  Deletion of IFNγ enhances hepatocarcinogenesis in FXR knockout mice.

Authors:  Zhipeng Meng; Xiaoqiong Wang; Yichao Gan; Yunfeng Zhang; Hong Zhou; Carl Van Ness; Jun Wu; Guiyu Lou; Hua Yu; Chao He; Rongzhen Xu; Wendong Huang
Journal:  J Hepatol       Date:  2012-06-21       Impact factor: 25.083

2.  JUNB/AP-1 controls IFN-γ during inflammatory liver disease.

Authors:  Martin K Thomsen; Latifa Bakiri; Sebastian C Hasenfuss; Rainer Hamacher; Lola Martinez; Erwin F Wagner
Journal:  J Clin Invest       Date:  2013-11-08       Impact factor: 14.808

3.  Correlations of IFN-γ genetic polymorphisms with susceptibility to breast cancer: a meta-analysis.

Authors:  Chun-Jiang Li; Yue Dai; Yan-Jun Fu; Jia-Ming Tian; Jin-Lun Li; Hong-Jun Lu; Feng Duan; Qing-Wang Li
Journal:  Tumour Biol       Date:  2014-04-16

4.  Innate immunity induced by Plasmodium liver infection inhibits malaria reinfections.

Authors:  Peter Liehl; Patrícia Meireles; Inês S Albuquerque; Mykola Pinkevych; Fernanda Baptista; Maria M Mota; Miles P Davenport; Miguel Prudêncio
Journal:  Infect Immun       Date:  2015-01-12       Impact factor: 3.441

5.  Poly-N-Acetylglucosamine Production by Staphylococcus epidermidis Cells Increases Their In Vivo Proinflammatory Effect.

Authors:  Pedro Ferreirinha; Begoña Pérez-Cabezas; Alexandra Correia; Bruna Miyazawa; Angela França; Virgínia Carvalhais; Augusto Faustino; Anabela Cordeiro-da-Silva; Luzia Teixeira; Gerald B Pier; Nuno Cerca; Manuel Vilanova
Journal:  Infect Immun       Date:  2016-09-19       Impact factor: 3.441

6.  The pseudokinase MLKL mediates programmed hepatocellular necrosis independently of RIPK3 during hepatitis.

Authors:  Claudia Günther; Gui-Wei He; Andreas E Kremer; James M Murphy; Emma J Petrie; Kerstin Amann; Peter Vandenabeele; Andreas Linkermann; Christopher Poremba; Ulrike Schleicher; Christin Dewitz; Stefan Krautwald; Markus F Neurath; Christoph Becker; Stefan Wirtz
Journal:  J Clin Invest       Date:  2016-10-17       Impact factor: 14.808

7.  Enhanced activation of human NK cells by drug-exposed hepatocytes.

Authors:  Frank Fasbender; Martin Obholzer; Sarah Metzler; Regina Stöber; Jan G Hengstler; Carsten Watzl
Journal:  Arch Toxicol       Date:  2020-02-14       Impact factor: 5.153

8.  Wedelolactone, a naturally occurring coumestan, enhances interferon-γ signaling through inhibiting STAT1 protein dephosphorylation.

Authors:  Zhimin Chen; Xiaoxiao Sun; Shensi Shen; Haohao Zhang; Xiuquan Ma; Jingli Liu; Shan Kuang; Qiang Yu
Journal:  J Biol Chem       Date:  2013-04-11       Impact factor: 5.157

9.  Genetic variants in STAT4 and HLA-DQ genes confer risk of hepatitis B virus-related hepatocellular carcinoma.

Authors:  De-Ke Jiang; Jielin Sun; Guangwen Cao; Yao Liu; Dongxin Lin; Yu-Zhen Gao; Wei-Hua Ren; Xi-Dai Long; Hongxing Zhang; Xiao-Pin Ma; Zhong Wang; Wei Jiang; Tao-Yang Chen; Yong Gao; Liang-Dan Sun; Ji-Rong Long; Hui-Xing Huang; Dan Wang; Hongjie Yu; Pengyin Zhang; Li-Sha Tang; Bo Peng; Hao Cai; Ting-Ting Liu; Ping Zhou; Fang Liu; Xiaoling Lin; Sha Tao; Bo Wan; He-Xi Ge Sai-Yin; Lun-Xiu Qin; Jianhua Yin; Li Liu; Chen Wu; Yan Pei; Yuan-Feng Zhou; Yun Zhai; Pei-Xin Lu; Aihua Tan; Xian-Bo Zuo; Jia Fan; Jiang Chang; Xiaoli Gu; Neng-Jin Wang; Yang Li; Yin-Kun Liu; Kan Zhai; Hongwei Zhang; Zhibin Hu; Jun Liu; Qing Yi; Yongbing Xiang; Rong Shi; Qiang Ding; Wei Zheng; Xiao-Ou Shu; Zengnan Mo; Yin Yao Shugart; Xue-Jun Zhang; Gangqiao Zhou; Hongbing Shen; S Lilly Zheng; Jianfeng Xu; Long Yu
Journal:  Nat Genet       Date:  2012-12-16       Impact factor: 38.330

10.   Fibrin-mediated integrin signaling plays a critical role in hepatic regeneration after partial hepatectomy in mice.

Authors:  Juliane I Beier; Luping Guo; Jeffrey D Ritzenthaler; Swati Joshi-Barve; Jesse Roman; Gavin E Arteel
Journal:  Ann Hepatol       Date:  2016 Sep-Oct       Impact factor: 2.400
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