| Literature DB >> 23242368 |
De-Ke Jiang1, Jielin Sun, Guangwen Cao, Yao Liu, Dongxin Lin, Yu-Zhen Gao, Wei-Hua Ren, Xi-Dai Long, Hongxing Zhang, Xiao-Pin Ma, Zhong Wang, Wei Jiang, Tao-Yang Chen, Yong Gao, Liang-Dan Sun, Ji-Rong Long, Hui-Xing Huang, Dan Wang, Hongjie Yu, Pengyin Zhang, Li-Sha Tang, Bo Peng, Hao Cai, Ting-Ting Liu, Ping Zhou, Fang Liu, Xiaoling Lin, Sha Tao, Bo Wan, He-Xi Ge Sai-Yin, Lun-Xiu Qin, Jianhua Yin, Li Liu, Chen Wu, Yan Pei, Yuan-Feng Zhou, Yun Zhai, Pei-Xin Lu, Aihua Tan, Xian-Bo Zuo, Jia Fan, Jiang Chang, Xiaoli Gu, Neng-Jin Wang, Yang Li, Yin-Kun Liu, Kan Zhai, Hongwei Zhang, Zhibin Hu, Jun Liu, Qing Yi, Yongbing Xiang, Rong Shi, Qiang Ding, Wei Zheng, Xiao-Ou Shu, Zengnan Mo, Yin Yao Shugart, Xue-Jun Zhang, Gangqiao Zhou, Hongbing Shen, S Lilly Zheng, Jianfeng Xu, Long Yu.
Abstract
To identify genetic susceptibility loci for hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) in the Chinese population, we carried out a genome-wide association study (GWAS) in 2,514 chronic HBV carriers (1,161 HCC cases and 1,353 controls) followed by a 2-stage validation among 6 independent populations of chronic HBV carriers (4,319 cases and 4,966 controls). The joint analyses showed that HCC risk was significantly associated with two independent loci: rs7574865 at STAT4, P(meta) = 2.48 × 10(-10), odds ratio (OR) = 1.21; and rs9275319 at HLA-DQ, P(meta) = 2.72 × 10(-17), OR = 1.49. The risk allele G at rs7574865 was significantly associated with lower mRNA levels of STAT4 in both the HCC tissues and nontumor tissues of 155 individuals with HBV-related HCC (P(trend) = 0.0008 and 0.0002, respectively). We also found significantly lower mRNA expression of STAT4 in HCC tumor tissues compared with paired adjacent nontumor tissues (P = 2.33 × 10(-14)).Entities:
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Year: 2012 PMID： 23242368 PMCID： PMC4105840 DOI： 10.1038/ng.2483
Source DB: PubMed Journal: Nat Genet ISSN： 1061-4036 Impact factor: 38.330