Literature DB >> 21334206

Antidotes to anthrax lethal factor intoxication. Part 2: structural modifications leading to improved in vivo efficacy.

Seongjin Kim1, Guan-Sheng Jiao, Mahtab Moayeri, Devorah Crown, Lynne Cregar-Hernandez, Linda McKasson, Stephen A Margosiak, Stephen H Leppla, Alan T Johnson.   

Abstract

New anthrax lethal factor inhibitors (LFIs) were designed based upon previously identified potent inhibitors 1a and 2. Combining the new core structures with modifications to the C2-side chain yielded analogs with improved efficacy in the rat lethal toxin model.
Copyright © 2011 Elsevier Ltd. All rights reserved.

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Year:  2011        PMID： 21334206      PMCID： PMC3059087          DOI： 10.1016/j.bmcl.2011.02.010

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  10 in total

1.  The structural basis for substrate and inhibitor selectivity of the anthrax lethal factor.

Authors:  Benjamin E Turk; Thiang Yian Wong; Robert Schwarzenbacher; Emily T Jarrell; Stephen H Leppla; R John Collier; Robert C Liddington; Lewis C Cantley
Journal:  Nat Struct Mol Biol       Date:  2003-12-29       Impact factor: 15.369

Review 2.  How many drug targets are there?

Authors:  John P Overington; Bissan Al-Lazikani; Andrew L Hopkins
Journal:  Nat Rev Drug Discov       Date:  2006-12       Impact factor: 84.694

3.  Antidotes to anthrax lethal factor intoxication. Part 1: Discovery of potent lethal factor inhibitors with in vivo efficacy.

Authors:  Guan-Sheng Jiao; Seongjin Kim; Mahtab Moayeri; Lynne Cregar-Hernandez; Linda McKasson; Stephen A Margosiak; Stephen H Leppla; Alan T Johnson
Journal:  Bioorg Med Chem Lett       Date:  2010-08-15       Impact factor: 2.823

4.  Anthrax lethal factor inhibition.

Authors:  W L Shoop; Y Xiong; J Wiltsie; A Woods; J Guo; J V Pivnichny; T Felcetto; B F Michael; A Bansal; R T Cummings; B R Cunningham; A M Friedlander; C M Douglas; S B Patel; D Wisniewski; G Scapin; S P Salowe; D M Zaller; K T Chapman; E M Scolnick; D M Schmatz; K Bartizal; M MacCoss; J D Hermes
Journal:  Proc Natl Acad Sci U S A       Date:  2005-05-23       Impact factor: 11.205

5.  Susceptibility to anthrax lethal toxin-induced rat death is controlled by a single chromosome 10 locus that includes rNlrp1.

Authors:  Zachary L Newman; Morton P Printz; Shihui Liu; Devorah Crown; Laura Breen; Sharmina Miller-Randolph; Pamela Flodman; Stephen H Leppla; Mahtab Moayeri
Journal:  PLoS Pathog       Date:  2010-05-20       Impact factor: 6.823

6.  Anthrax toxin: causative agent in the death of rhesus monkeys.

Authors:  F KLEIN; D R HODGES; B G MAHLANDT; W I JONES; B W HAINES; R E LINCOLN
Journal:  Science       Date:  1962-12-21       Impact factor: 47.728

Review 7.  Cellular and systemic effects of anthrax lethal toxin and edema toxin.

Authors:  Mahtab Moayeri; Stephen H Leppla
Journal:  Mol Aspects Med       Date:  2009-07-26

8.  Contribution of individual toxin components to virulence of Bacillus anthracis.

Authors:  C Pezard; P Berche; M Mock
Journal:  Infect Immun       Date:  1991-10       Impact factor: 3.441

9.  Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

Authors:  Jennifer Venhorst; Antonius M ter Laak; Jan N M Commandeur; Yoshihiko Funae; Toyoko Hiroi; Nico P E Vermeulen
Journal:  J Med Chem       Date:  2003-01-02       Impact factor: 7.446

10.  Bioterrorism-related inhalational anthrax: the first 10 cases reported in the United States.

Authors:  J A Jernigan; D S Stephens; D A Ashford; C Omenaca; M S Topiel; M Galbraith; M Tapper; T L Fisk; S Zaki; T Popovic; R F Meyer; C P Quinn; S A Harper; S K Fridkin; J J Sejvar; C W Shepard; M McConnell; J Guarner; W J Shieh; J M Malecki; J L Gerberding; J M Hughes; B A Perkins
Journal:  Emerg Infect Dis       Date:  2001 Nov-Dec       Impact factor: 6.883
  10 in total
  9 in total

Review 1.  Targeting Metalloenzymes for Therapeutic Intervention.

Authors:  Allie Y Chen; Rebecca N Adamek; Benjamin L Dick; Cy V Credille; Christine N Morrison; Seth M Cohen
Journal:  Chem Rev       Date:  2018-09-07       Impact factor: 60.622

Review 2.  Designing inhibitors of anthrax toxin.

Authors:  Ekaterina M Nestorovich; Sergey M Bezrukov
Journal:  Expert Opin Drug Discov       Date:  2014-01-22       Impact factor: 6.098

3.  Antidotes to anthrax lethal factor intoxication. Part 3: Evaluation of core structures and further modifications to the C2-side chain.

Authors:  Guan-Sheng Jiao; Seongjin Kim; Mahtab Moayeri; Devorah Crown; April Thai; Lynne Cregar-Hernandez; Linda McKasson; Banumathi Sankaran; Axel Lehrer; Teri Wong; Lisa Johns; Stephen A Margosiak; Stephen H Leppla; Alan T Johnson
Journal:  Bioorg Med Chem Lett       Date:  2012-02-01       Impact factor: 2.823

Review 4.  An overview of investigational toxin-directed therapies for the adjunctive management of Bacillus anthracis infection and sepsis.

Authors:  Lernik Ohanjanian; Kenneth E Remy; Yan Li; Xizhong Cui; Peter Q Eichacker
Journal:  Expert Opin Investig Drugs       Date:  2015-04-28       Impact factor: 6.206

5.  Development of a comprehensive, validated pharmacophore hypothesis for anthrax toxin lethal factor (LF) inhibitors using genetic algorithms, Pareto scoring, and structural biology.

Authors:  Ting-Lan Chiu; Elizabeth A Amin
Journal:  J Chem Inf Model       Date:  2012-06-25       Impact factor: 4.956

6.  Highly predictive support vector machine (SVM) models for anthrax toxin lethal factor (LF) inhibitors.

Authors:  Xia Zhang; Elizabeth Ambrose Amin
Journal:  J Mol Graph Model       Date:  2015-11-17       Impact factor: 2.518

7.  Small-molecule inhibitors of lethal factor protease activity protect against anthrax infection.

Authors:  Mahtab Moayeri; Devorah Crown; Guan-Sheng Jiao; Seongjin Kim; Alan Johnson; Clinton Leysath; Stephen H Leppla
Journal:  Antimicrob Agents Chemother       Date:  2013-06-17       Impact factor: 5.191

Review 8.  Inhibitors of the Metalloproteinase Anthrax Lethal Factor.

Authors:  Allison B Goldberg; Benjamin E Turk
Journal:  Curr Top Med Chem       Date:  2016       Impact factor: 3.295

9.  Rational Design 2-Hydroxypropylphosphonium Salts as Cancer Cell Mitochondria-Targeted Vectors: Synthesis, Structure, and Biological Properties.

Authors:  Vladimir F Mironov; Andrey V Nemtarev; Olga V Tsepaeva; Mudaris N Dimukhametov; Igor A Litvinov; Alexandra D Voloshina; Tatiana N Pashirova; Eugenii A Titov; Anna P Lyubina; Syumbelya K Amerhanova; Aidar T Gubaidullin; Daut R Islamov
Journal:  Molecules       Date:  2021-10-20       Impact factor: 4.411
  9 in total

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