Literature DB >> 19638283

Cellular and systemic effects of anthrax lethal toxin and edema toxin.

Mahtab Moayeri1, Stephen H Leppla.   

Abstract

Anthrax lethal toxin (LT) and edema toxin (ET) are the major virulence factors of anthrax and can replicate the lethality and symptoms associated with the disease. This review provides an overview of our current understanding of anthrax toxin effects in animal models and the cytotoxicity (necrosis and apoptosis) induced by LT in different cells. A brief reexamination of early historic findings on toxin in vivo effects in the context of our current knowledge is also presented.

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Year:  2009        PMID： 19638283      PMCID： PMC2784088          DOI： 10.1016/j.mam.2009.07.003

Source DB:  PubMed          Journal:  Mol Aspects Med        ISSN： 0098-2997


  144 in total

1.  The three Bacillus anthracis toxin genes are coordinately regulated by bicarbonate and temperature.

Authors:  J C Sirard; M Mock; A Fouet
Journal:  J Bacteriol       Date:  1994-08       Impact factor: 3.490

2.  Anthrax oedema toxin induces anthrax toxin receptor expression in monocyte-derived cells.

Authors:  Francisco J Maldonado-Arocho; Jennifer A Fulcher; Benhur Lee; Kenneth A Bradley
Journal:  Mol Microbiol       Date:  2006-07       Impact factor: 3.501

3.  Toxin-deficient mutants of Bacillus anthracis are lethal in a murine model for pulmonary anthrax.

Authors:  Sara Heninger; Melissa Drysdale; Julie Lovchik; Julie Hutt; Mary F Lipscomb; Theresa M Koehler; C Rick Lyons
Journal:  Infect Immun       Date:  2006-08-21       Impact factor: 3.441

4.  Ltx1, a mouse locus that influences the susceptibility of macrophages to cytolysis caused by intoxication with Bacillus anthracis lethal factor, maps to chromosome 11.

Authors:  J E Roberts; J W Watters; J D Ballard; W F Dietrich
Journal:  Mol Microbiol       Date:  1998-07       Impact factor: 3.501

5.  Suppression of dendritic cell activation by anthrax lethal toxin and edema toxin depends on multiple factors including cell source, stimulus used, and function tested.

Authors:  Ping-Jen Joe Chou; Catherine A Newton; Izabella Perkins; Herman Friedman; Thomas W Klein
Journal:  DNA Cell Biol       Date:  2008-12       Impact factor: 3.311

6.  Inhibition of MAPK kinase signaling pathways suppressed renal cell carcinoma growth and angiogenesis in vivo.

Authors:  Dan Huang; Yan Ding; Wang-Mei Luo; Stephanie Bender; Chao-Nan Qian; Eric Kort; Zhong-Fa Zhang; Kristin VandenBeldt; Nicholas S Duesbery; James H Resau; Bin Tean Teh
Journal:  Cancer Res       Date:  2008-01-01       Impact factor: 12.701

7.  Characterization of macrophage sensitivity and resistance to anthrax lethal toxin.

Authors:  A M Friedlander; R Bhatnagar; S H Leppla; L Johnson; Y Singh
Journal:  Infect Immun       Date:  1993-01       Impact factor: 3.441

8.  Calcium is required for the expression of anthrax lethal toxin activity in the macrophagelike cell line J774A.1.

Authors:  R Bhatnagar; Y Singh; S H Leppla; A M Friedlander
Journal:  Infect Immun       Date:  1989-07       Impact factor: 3.441

9.  Contribution of individual toxin components to virulence of Bacillus anthracis.

Authors:  C Pezard; P Berche; M Mock
Journal:  Infect Immun       Date:  1991-10       Impact factor: 3.441

10.  Macrophages are sensitive to anthrax lethal toxin through an acid-dependent process.

Authors:  A M Friedlander
Journal:  J Biol Chem       Date:  1986-06-05       Impact factor: 5.157
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  130 in total

1.  Impaired function of the Tie-2 receptor contributes to vascular leakage and lethality in anthrax.

Authors:  Chandra C Ghosh; Aditi Mukherjee; Sascha David; Ulla G Knaus; Deborah J Stearns-Kurosawa; Shinichiro Kurosawa; Samir M Parikh
Journal:  Proc Natl Acad Sci U S A       Date:  2012-06-04       Impact factor: 11.205

Review 2.  New insights into the biological effects of anthrax toxins: linking cellular to organismal responses.

Authors:  Annabel Guichard; Victor Nizet; Ethan Bier
Journal:  Microbes Infect       Date:  2011-09-08       Impact factor: 2.700

3.  Contribution of lethal toxin and edema toxin to the pathogenesis of anthrax meningitis.

Authors:  Celia M Ebrahimi; Tamsin R Sheen; Christian W Renken; Roberta A Gottlieb; Kelly S Doran
Journal:  Infect Immun       Date:  2011-04-25       Impact factor: 3.441

4.  Anthrax toxin targeting of myeloid cells through the CMG2 receptor is essential for establishment of Bacillus anthracis infections in mice.

Authors:  Shihui Liu; Sharmina Miller-Randolph; Devorah Crown; Mahtab Moayeri; Inka Sastalla; Shu Okugawa; Stephen H Leppla
Journal:  Cell Host Microbe       Date:  2010-11-18       Impact factor: 21.023

5.  Binding of filamentous actin to anthrax toxin receptor 1 decreases its association with protective antigen.

Authors:  Kristopher M Garlick; Sarah Batty; Jeremy Mogridge
Journal:  Biochemistry       Date:  2012-02-03       Impact factor: 3.162

6.  Anthrax toxin delivers a one-two punch.

Authors:  Kenneth A Bradley; Steven M LeVine
Journal:  Cell Host Microbe       Date:  2010-11-18       Impact factor: 21.023

7.  Key tissue targets responsible for anthrax-toxin-induced lethality.

Authors:  Shihui Liu; Yi Zhang; Mahtab Moayeri; Jie Liu; Devorah Crown; Rasem J Fattah; Alexander N Wein; Zu-Xi Yu; Toren Finkel; Stephen H Leppla
Journal:  Nature       Date:  2013-08-28       Impact factor: 49.962

8.  Human genetic variation altering anthrax toxin sensitivity.

Authors:  Mikhail Martchenko; Sophie I Candille; Hua Tang; Stanley N Cohen
Journal:  Proc Natl Acad Sci U S A       Date:  2012-02-06       Impact factor: 11.205

9.  B. anthracis edema toxin increases cAMP levels and inhibits phenylephrine-stimulated contraction in a rat aortic ring model.

Authors:  Yan Li; Xizhong Cui; Steven B Solomon; Kenneth Remy; Yvonne Fitz; Peter Q Eichacker
Journal:  Am J Physiol Heart Circ Physiol       Date:  2013-04-12       Impact factor: 4.733

10.  Identification of exosite-targeting inhibitors of anthrax lethal factor by high-throughput screening.

Authors:  Ludovic Bannwarth; Allison B Goldberg; Catherine Chen; Benjamin E Turk
Journal:  Chem Biol       Date:  2012-07-27
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