Voluntary quadriceps activation deficits in patients with tibiofemoral osteoarthritis: a meta-analysis.

The objective of this study was to assess the magnitude of quadriceps activation deficits in the involved extremity and contralateral extremity of patients with knee joint osteoarthritis (OA), as well as matched controls. An exhaustive search of the literature was performed using Web of Science between 1970 and February 24, 2010, using the search terms "osteoarthritis" AND "quadriceps activation" OR "quadriceps inhibition" and cross-referencing pertinent articles. Studies written in English reporting quadriceps activation means and standard deviations in patients with tibiofemoral OA via a method using an exogenous electrical stimulation were evaluated for methodological quality and were included for data analysis. Fourteen individual studies met the criteria for inclusion into data analysis. The number of participants and mean activation levels were used to calculate weighted means for the involved limb (14 studies), the contralateral limb (from a subset of 6 studies), and an involved limb subset from only the studies evaluating the contralateral limb and population of control subjects (5 studies). Weighted means from the involved limb (82.2; 95% CI = 81.4-83.3%), contralateral limb (81.7; 80.1-83.3%), and involved limb subset (76.8; 74.8-78.8%) groups were found to have lower volitional quadriceps activation compared with the control groups (90; 88.9-91.7%). Although the weighted involved limb mean was not different from that of the contralateral limb, the mean and 95% confidence intervals for the involved limb subset were lower than that of the contralateral limb group, suggesting that the involved limb had less volitional activation within OA subjects. This provides evidence that bilateral quadriceps volitional activation deficits are present in persons with knee OA.