BACKGROUND/AIMS: We aimed to evaluate the prevalence of non-alcoholic steatohepatitis and metabolic syndrome in patients with symptomatic gallstones undergoing laparoscopic or open cholecystectomy. METHODS: A study of 95 patients was performed. Simultaneous liver biopsies were taken during cholecystectomy between 2006 and 2007. There were no postoperative complications. Patients with significant alcohol intake, hepatitis B or C (virus-positive), autoimmune diseases, and Wilson's disease were excluded. Demographics, liver function tests, lipid profile, and ultrasound findings of patients with and without non-alcoholic steatohepatitis were compared. RESULTS: A total of 95 patients completed the study. The mean age was 52.15 years, and 29 patients were male and 66 female. Fifty-two patients (55%) had biopsies compatible with non-alcoholic steatohepatitis. CONCLUSIONS: Fifty-five percent of patients with gallbladder stones had associated non-alcoholic steatohepatitis. Awareness of this association may result in an earlier diagnosis. The high prevalence of non-alcoholic steatohepatitis in patients with gallbladder stone may justify routine liver biopsy during cholecystectomy to establish the diagnosis and stage and possibly direct therapy.
BACKGROUND/AIMS: We aimed to evaluate the prevalence of non-alcoholic steatohepatitis and metabolic syndrome in patients with symptomatic gallstones undergoing laparoscopic or open cholecystectomy. METHODS: A study of 95 patients was performed. Simultaneous liver biopsies were taken during cholecystectomy between 2006 and 2007. There were no postoperative complications. Patients with significant alcohol intake, hepatitis B or C (virus-positive), autoimmune diseases, and Wilson's disease were excluded. Demographics, liver function tests, lipid profile, and ultrasound findings of patients with and without non-alcoholic steatohepatitis were compared. RESULTS: A total of 95 patients completed the study. The mean age was 52.15 years, and 29 patients were male and 66 female. Fifty-two patients (55%) had biopsies compatible with non-alcoholic steatohepatitis. CONCLUSIONS: Fifty-five percent of patients with gallbladder stones had associated non-alcoholic steatohepatitis. Awareness of this association may result in an earlier diagnosis. The high prevalence of non-alcoholic steatohepatitis in patients with gallbladder stone may justify routine liver biopsy during cholecystectomy to establish the diagnosis and stage and possibly direct therapy.
Authors: Michael H Ma; Harrison X Bai; Alexander J Park; Sahibzada U Latif; Pramod K Mistry; Dinesh Pashankar; Veronika S Northrup; Vineet Bhandari; Sohail Z Husain Journal: J Pediatr Gastroenterol Nutr Date: 2012-05 Impact factor: 2.839
Authors: Faisal A Alsaif; Sara H Alqahtani; Amani M Alsadoon; Khalid A Alswat; Ayman A Abdo; Mazen M Hassanain; Abdulsalam B Alsharabi; Ghadeer R Aljuhani; Hisham M Alkhalidi; Mohammad S Elsharkawy; Maram A Alotaibi; Faisal M Sanai; Waleed K Al-Hamoudi Journal: Saudi J Gastroenterol Date: 2020-04-14 Impact factor: 2.485