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Literature DB >> 21326907

Mediator and post-recruitment regulation of RNA polymerase II.

Abstract

The human Mediator complex interacts extensively with the RNA polymerase II (Pol II) enzyme and recent data from our lab suggest activator-induced structural shifts within Mediator trigger activation of stalled Pol II. These results are discussed together with other recent findings regarding post-recruitment regulation of Pol II.

Entities: Gene Species

Keywords: CDK8; DSIF; Myc; NELF; P-TEFb; p53; review

Mesh：

Substances：

Year: 2011 PMID： 21326907 PMCID： PMC3023644 DOI： 10.4161/trns.2.1.13950

Source DB: PubMed Journal: Transcription ISSN： 2154-1272

43 in total

1. Structure, function, and activator-induced conformations of the CRSP coactivator.

Authors: Dylan J Taatjes; Anders M Näär; Frank Andel; Eva Nogales; Robert Tjian
Journal: Science Date: 2002-02-08 Impact factor: 47.728

2. Nascent RNA sequencing reveals widespread pausing and divergent initiation at human promoters.

Authors: Leighton J Core; Joshua J Waterfall; John T Lis
Journal: Science Date: 2008-12-04 Impact factor: 47.728

3. The human CDK8 subcomplex is a histone kinase that requires Med12 for activity and can function independently of mediator.

Authors: Matthew T Knuesel; Krista D Meyer; Aaron J Donner; Joaquin M Espinosa; Dylan J Taatjes
Journal: Mol Cell Biol Date: 2008-12-01 Impact factor: 4.272

4. Cooperative activity of cdk8 and GCN5L within Mediator directs tandem phosphoacetylation of histone H3.

Authors: Krista D Meyer; Aaron J Donner; Matthew T Knuesel; Autumn G York; Joaquín M Espinosa; Dylan J Taatjes
Journal: EMBO J Date: 2008-04-17 Impact factor: 11.598

5. c-Myc regulates transcriptional pause release.

Authors: Peter B Rahl; Charles Y Lin; Amy C Seila; Ryan A Flynn; Scott McCuine; Christopher B Burge; Phillip A Sharp; Richard A Young
Journal: Cell Date: 2010-04-30 Impact factor: 41.582

6. c-Myc mediates activation of the cad promoter via a post-RNA polymerase II recruitment mechanism.

Authors: S R Eberhardy; P J Farnham
Journal: J Biol Chem Date: 2001-10-22 Impact factor: 5.157

7. Global analysis of short RNAs reveals widespread promoter-proximal stalling and arrest of Pol II in Drosophila.

Authors: Sergei Nechaev; David C Fargo; Gilberto dos Santos; Liwen Liu; Yuan Gao; Karen Adelman
Journal: Science Date: 2009-12-10 Impact factor: 47.728

8. Human CRSP interacts with RNA polymerase II CTD and adopts a specific CTD-bound conformation.

Authors: Anders M Näär; Dylan J Taatjes; Weiguo Zhai; Eva Nogales; Robert Tjian
Journal: Genes Dev Date: 2002-06-01 Impact factor: 11.361

9. p53 activates transcription by directing structural shifts in Mediator.

Authors: Krista D Meyer; Shih-Chieh Lin; Carrie Bernecky; Yuefeng Gao; Dylan J Taatjes
Journal: Nat Struct Mol Biol Date: 2010-05-09 Impact factor: 15.369

10. CDK8 is a positive regulator of transcriptional elongation within the serum response network.

Authors: Aaron J Donner; Christopher C Ebmeier; Dylan J Taatjes; Joaquín M Espinosa
Journal: Nat Struct Mol Biol Date: 2010-01-24 Impact factor: 15.369

16 in total

Review 1. MYC and transcription elongation.

Authors: Peter B Rahl; Richard A Young
Journal: Cold Spring Harb Perspect Med Date: 2014-01-01 Impact factor: 6.915

2. Disruption of cardiac Med1 inhibits RNA polymerase II promoter occupancy and promotes chromatin remodeling.

Authors: Duane D Hall; Kathryn M Spitler; Chad E Grueter
Journal: Am J Physiol Heart Circ Physiol Date: 2018-11-21 Impact factor: 4.733

3. Regulation of androgen receptor-dependent transcription by coactivator MED1 is mediated through a newly discovered noncanonical binding motif.

Authors: Feng Jin; Frank Claessens; Joseph D Fondell
Journal: J Biol Chem Date: 2011-11-18 Impact factor: 5.157

4. Small molecule probes to target the human Mediator complex.

Authors: Andrew J Phillips; Dylan J Taatjes
Journal: Isr J Chem Date: 2013-08 Impact factor: 3.333

Review 5. Mediator kinase module and human tumorigenesis.

Authors: Alison D Clark; Marieke Oldenbroek; Thomas G Boyer
Journal: Crit Rev Biochem Mol Biol Date: 2015-07-16 Impact factor: 8.250

6. Transcriptional activation of lipogenesis by insulin requires phosphorylation of MED17 by CK2.

Authors: Jose A Viscarra; Yuhui Wang; Il-Hwa Hong; Hei Sook Sul
Journal: Sci Signal Date: 2017-02-21 Impact factor: 8.192

7. Mediator MED23 regulates basal transcription in vivo via an interaction with P-TEFb.

Authors: Wei Wang; Xiao Yao; Yan Huang; Xiangming Hu; Runzhong Liu; Dongming Hou; Ruichuan Chen; Gang Wang
Journal: Transcription Date: 2013 Jan-Feb

Review 8. Glucocorticoid receptor control of transcription: precision and plasticity via allostery.

Authors: Emily R Weikum; Matthew T Knuesel; Eric A Ortlund; Keith R Yamamoto
Journal: Nat Rev Mol Cell Biol Date: 2017-01-05 Impact factor: 94.444

Review 9. The Mediator complex and transcription regulation.

Authors: Zachary C Poss; Christopher C Ebmeier; Dylan J Taatjes
Journal: Crit Rev Biochem Mol Biol Date: 2013-10-03 Impact factor: 8.250

10. Protein network study of human AF4 reveals its central role in RNA Pol II-mediated transcription and in phosphorylation-dependent regulatory mechanisms.

Authors: Gabriella Esposito; Armando Cevenini; Alessandro Cuomo; Francesca de Falco; Dario Sabbatino; Fabrizio Pane; Margherita Ruoppolo; Francesco Salvatore
Journal: Biochem J Date: 2011-08-15 Impact factor: 3.857