Literature DB >> 21326900

Transcription and replication: breaking the rules of the road causes genomic instability.

Ana Maria Poveda1, Mikael Le Clech, Philippe Pasero.   

Abstract

Replication and transcription machineries progress at high speed on the same DNA template, which inevitably causes traffic accidents. Problems are not only caused by frontal collisions between polymerases, but also by cotranscriptional R-loops. These RNA-DNA hybrids induce genomic instability by blocking fork progression and could be implicated in the development of cancer.

Entities:  

Keywords:  DNA replication; R-loops; genomic instability; transcription-associated recombination

Mesh：

Substances：

Year:  2010        PMID： 21326900      PMCID： PMC3023637          DOI： 10.4161/trns.1.2.12665

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  42 in total

Review 1.  The organization of replication and transcription.

Authors:  P R Cook
Journal:  Science       Date:  1999-06-11       Impact factor: 47.728

Review 2.  Replication fork pausing and recombination or "gimme a break".

Authors:  R Rothstein; B Michel; S Gangloff
Journal:  Genes Dev       Date:  2000-01-01       Impact factor: 11.361

Review 3.  The connection between transcription and genomic instability.

Authors:  Andrés Aguilera
Journal:  EMBO J       Date:  2002-02-01       Impact factor: 11.598

4.  R-loops at immunoglobulin class switch regions in the chromosomes of stimulated B cells.

Authors:  Kefei Yu; Frederic Chedin; Chih-Lin Hsieh; Thomas E Wilson; Michael R Lieber
Journal:  Nat Immunol       Date:  2003-05       Impact factor: 25.606

5.  Cotranscriptionally formed DNA:RNA hybrids mediate transcription elongation impairment and transcription-associated recombination.

Authors:  Pablo Huertas; Andrés Aguilera
Journal:  Mol Cell       Date:  2003-09       Impact factor: 17.970

6.  Single-molecule analysis reveals clustering and epigenetic regulation of replication origins at the yeast rDNA locus.

Authors:  Philippe Pasero; Aaron Bensimon; Etienne Schwob
Journal:  Genes Dev       Date:  2002-10-01       Impact factor: 11.361

7.  Termination of mammalian rDNA replication: polar arrest of replication fork movement by transcription termination factor TTF-I.

Authors:  J K Gerber; E Gögel; C Berger; M Wallisch; F Müller; I Grummt; F Grummt
Journal:  Cell       Date:  1997-08-08       Impact factor: 41.582

8.  Direct restart of a replication fork stalled by a head-on RNA polymerase.

Authors:  Richard T Pomerantz; Mike O'Donnell
Journal:  Science       Date:  2010-01-29       Impact factor: 47.728

9.  Transcription-dependent recombination and the role of fork collision in yeast rDNA.

Authors:  Yasushi Takeuchi; Takashi Horiuchi; Takehiko Kobayashi
Journal:  Genes Dev       Date:  2003-06-03       Impact factor: 11.361

10.  The Saccharomyces cerevisiae helicase Rrm3p facilitates replication past nonhistone protein-DNA complexes.

Authors:  Andreas S Ivessa; Brian A Lenzmeier; Jessica B Bessler; Lara K Goudsouzian; Sandra L Schnakenberg; Virginia A Zakian
Journal:  Mol Cell       Date:  2003-12       Impact factor: 17.970
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  16 in total

1.  Thresholds of replication stress signaling in cancer development and treatment.

Authors:  Jiri Bartek; Martin Mistrik; Jirina Bartkova
Journal:  Nat Struct Mol Biol       Date:  2012-01-05       Impact factor: 15.369

2.  Interaction with Single-stranded DNA-binding Protein Stimulates Escherichia coli Ribonuclease HI Enzymatic Activity.

Authors:  Christine Petzold; Aimee H Marceau; Katherine H Miller; Susan Marqusee; James L Keck
Journal:  J Biol Chem       Date:  2015-04-22       Impact factor: 5.157

3.  Telomeric RNA-DNA hybrids affect telomere-length dynamics and senescence.

Authors:  Bettina Balk; André Maicher; Martina Dees; Julia Klermund; Sarah Luke-Glaser; Katharina Bender; Brian Luke
Journal:  Nat Struct Mol Biol       Date:  2013-09-08       Impact factor: 15.369

4.  R-Loop Depletion by Over-expressed RNase H1 in Mouse B Cells Increases Activation-Induced Deaminase Access to the Transcribed Strand without Altering Frequency of Isotype Switching.

Authors:  Robert W Maul; Hyongi Chon; Kiran Sakhuja; Susana M Cerritelli; Lina A Gugliotti; Patricia J Gearhart; Robert J Crouch
Journal:  J Mol Biol       Date:  2017-01-06       Impact factor: 5.469

5.  Transcriptional responses to loss of RNase H2 in Saccharomyces cerevisiae.

Authors:  Mercedes E Arana; Robnet T Kerns; Laura Wharey; Kevin E Gerrish; Pierre R Bushel; Thomas A Kunkel
Journal:  DNA Repair (Amst)       Date:  2012-10-15

6.  Deregulated telomere transcription causes replication-dependent telomere shortening and promotes cellular senescence.

Authors:  André Maicher; Lisa Kastner; Martina Dees; Brian Luke
Journal:  Nucleic Acids Res       Date:  2012-05-02       Impact factor: 16.971

7.  Phosphoinositide 3-kinase beta controls replication factor C assembly and function.

Authors:  Javier Redondo-Muñoz; María Josefa Rodríguez; Virginia Silió; Vicente Pérez-García; José María Valpuesta; Ana C Carrera
Journal:  Nucleic Acids Res       Date:  2012-11-21       Impact factor: 16.971

8.  Genome maintenance and transcription integrity in aging and disease.

Authors:  Stefanie Wolters; Björn Schumacher
Journal:  Front Genet       Date:  2013-02-25       Impact factor: 4.599

9.  Mitochondrial transcription terminator family members mTTF and mTerf5 have opposing roles in coordination of mtDNA synthesis.

Authors:  Priit Jõers; Samantha C Lewis; Atsushi Fukuoh; Mikael Parhiala; Simo Ellilä; Ian J Holt; Howard T Jacobs
Journal:  PLoS Genet       Date:  2013-09-19       Impact factor: 5.917

10.  Identification of Multiple Proteins Coupling Transcriptional Gene Silencing to Genome Stability in Arabidopsis thaliana.

Authors:  Christopher J Hale; Magdalena E Potok; Jennifer Lopez; Truman Do; Ao Liu; Javier Gallego-Bartolome; Scott D Michaels; Steven E Jacobsen
Journal:  PLoS Genet       Date:  2016-06-02       Impact factor: 5.917
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