Literature DB >> 21326896

Yin Yang 1: a multifaceted protein beyond a transcription factor.

Zhiyong Deng1, Paul Cao, Mei Mei Wan, Guangchao Sui.   

Abstract

As a transcription factor, Yin Yang 1 (YY1) regulates the transcription of a dazzling list of genes and the number of its targets still mounts. Recent studies revealed that YY1 possesses functions independent of its DNA binding activity and its regulatory role in tumorigenesis has started to emerge.

Entities:  

Keywords:  Yin Yang 1; androgen receptor; coactivator; prostate cancer; protein modification; transcription factor

Mesh：

Substances：

Year:  2010        PMID： 21326896      PMCID： PMC3023633          DOI： 10.4161/trns.1.2.12375

Source DB:  PubMed          Journal:  Transcription        ISSN： 2154-1272


  29 in total

1.  Transcriptional repression by YY1, a human GLI-Krüppel-related protein, and relief of repression by adenovirus E1A protein.

Authors:  Y Shi; E Seto; L S Chang; T Shenk
Journal:  Cell       Date:  1991-10-18       Impact factor: 41.582

2.  High affinity YY1 binding motifs: identification of two core types (ACAT and CCAT) and distribution of potential binding sites within the human beta globin cluster.

Authors:  S R Yant; W Zhu; D Millinoff; J L Slightom; M Goodman; D L Gumucio
Journal:  Nucleic Acids Res       Date:  1995-11-11       Impact factor: 16.971

3.  Negative effect of the transcriptional activator GAL4.

Authors:  G Gill; M Ptashne
Journal:  Nature       Date:  1988-08-25       Impact factor: 49.962

4.  Failure of hormone therapy in prostate cancer involves systematic restoration of androgen responsive genes and activation of rapamycin sensitive signaling.

Authors:  S Mousses; U Wagner; Y Chen; J W Kim; L Bubendorf; M Bittner; T Pretlow; A G Elkahloun; J B Trepel; O P Kallioniemi
Journal:  Oncogene       Date:  2001-10-11       Impact factor: 9.867

Review 5.  Post-translational modification of p53 in tumorigenesis.

Authors:  Ann M Bode; Zigang Dong
Journal:  Nat Rev Cancer       Date:  2004-10       Impact factor: 60.716

6.  Relief of YY1 transcriptional repression by adenovirus E1A is mediated by E1A-associated protein p300.

Authors:  J S Lee; K M Galvin; R H See; R Eckner; D Livingston; E Moran; Y Shi
Journal:  Genes Dev       Date:  1995-05-15       Impact factor: 11.361

7.  YY1 inhibits the activation of the p53 tumor suppressor in response to genotoxic stress.

Authors:  Eva Grönroos; Alexei A Terentiev; Tanel Punga; Johan Ericsson
Journal:  Proc Natl Acad Sci U S A       Date:  2004-08-04       Impact factor: 11.205

8.  The Yin Yang-1 (YY1) protein undergoes a DNA-replication-associated switch in localization from the cytoplasm to the nucleus at the onset of S phase.

Authors:  Linda Palko; Hank W Bass; Maroun J Beyrouthy; Myra M Hurt
Journal:  J Cell Sci       Date:  2004-01-26       Impact factor: 5.285

Review 9.  Contribution of the androgen receptor to prostate cancer predisposition and progression.

Authors:  G Buchanan; R A Irvine; G A Coetzee; W D Tilley
Journal:  Cancer Metastasis Rev       Date:  2001       Impact factor: 9.264

10.  Yin Yang 1 is a negative regulator of p53.

Authors:  Guangchao Sui; El Bachir Affar; Yujiang Shi; Chrystelle Brignone; Nathan R Wall; Peng Yin; Mary Donohoe; Margaret P Luke; Dominica Calvo; Steven R Grossman; Yang Shi
Journal:  Cell       Date:  2004-06-25       Impact factor: 41.582
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  59 in total

1.  Shadow enhancers enable Hunchback bifunctionality in the Drosophila embryo.

Authors:  Max V Staller; Ben J Vincent; Meghan D J Bragdon; Tara Lydiard-Martin; Zeba Wunderlich; Javier Estrada; Angela H DePace
Journal:  Proc Natl Acad Sci U S A       Date:  2015-01-06       Impact factor: 11.205

2.  Yin Yang 1 plays an essential role in breast cancer and negatively regulates p27.

Authors:  Meimei Wan; Weiwei Huang; Timothy E Kute; Lance D Miller; Qiang Zhang; Heather Hatcher; Jingxuan Wang; Daniel B Stovall; Gregory B Russell; Paul D Cao; Zhiyong Deng; Wei Wang; Qingyuan Zhang; Ming Lei; Suzy V Torti; Steven A Akman; Guangchao Sui
Journal:  Am J Pathol       Date:  2012-03-20       Impact factor: 4.307

3.  Negative regulation of JAK2 by H3K9 methyltransferase G9a in leukemia.

Authors:  Hye-Ju Son; Ji-Young Kim; Yoonsoo Hahn; Sang-Beom Seo
Journal:  Mol Cell Biol       Date:  2012-07-16       Impact factor: 4.272

Review 4.  Role of transcription factor yin yang 1 in manganese-induced reduction of astrocytic glutamate transporters: Putative mechanism for manganese-induced neurotoxicity.

Authors:  Pratap Karki; Keisha Smith; James Johnson; Michael Aschner; Eunsook Lee
Journal:  Neurochem Int       Date:  2014-08-13       Impact factor: 3.921

5.  YY1 binds to the E3' enhancer and inhibits the expression of the immunoglobulin κ gene via epigenetic modifications.

Authors:  Xiaorong Zhou; Weiwei Xian; Jie Zhang; Yiqing Zhu; Xiaoyi Shao; Yu Han; Yue Qi; Xiaoling Ding; Xiaoying Wang
Journal:  Immunology       Date:  2018-08-29       Impact factor: 7.397

Review 6.  The oncogenic role of Yin Yang 1.

Authors:  Qiang Zhang; Daniel B Stovall; Kazushi Inoue; Guangchao Sui
Journal:  Crit Rev Oncog       Date:  2011

7.  Canonical Wnt/β-catenin activity and differential epigenetic marks direct sexually dimorphic regulation of Irx3 and Irx5 in developing mouse gonads.

Authors:  Megan L Koth; S Alexandra Garcia-Moreno; Annie Novak; Kirsten A Holthusen; Anbarasi Kothandapani; Keer Jiang; Makoto Mark Taketo; Barbara Nicol; Humphrey H-C Yao; Christopher R Futtner; Danielle M Maatouk; Joan S Jorgensen
Journal:  Development       Date:  2020-03-30       Impact factor: 6.868

8.  An Ultraconserved Brain-Specific Enhancer Within ADGRL3 (LPHN3) Underpins Attention-Deficit/Hyperactivity Disorder Susceptibility.

Authors:  Ariel F Martinez; Yu Abe; Sungkook Hong; Kevin Molyneux; David Yarnell; Heiko Löhr; Wolfgang Driever; Maria T Acosta; Mauricio Arcos-Burgos; Maximilian Muenke
Journal:  Biol Psychiatry       Date:  2016-07-14       Impact factor: 13.382

9.  Yin Yang 1 is a repressor of glutamate transporter EAAT2, and it mediates manganese-induced decrease of EAAT2 expression in astrocytes.

Authors:  Pratap Karki; Anton Webb; Keisha Smith; James Johnson; Kyuwon Lee; Deok-Soo Son; Michael Aschner; Eunsook Lee
Journal:  Mol Cell Biol       Date:  2014-01-27       Impact factor: 4.272

10.  Yin-yang and Zheng: Exported from Chinese medicine.

Authors:  Hong-ji Zhang; Zhan-xiang Wang
Journal:  Chin J Integr Med       Date:  2014-04-03       Impact factor: 1.978
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