| Literature DB >> 2132569 |
T Oki1, M Kakushima, M Nishio, H Kamei, M Hirano, Y Sawada, M Konishi.
Abstract
Three N,N-dimethyl pradimicins were synthesized by reductive alkylation of pradimicins A, E and FA-2 and evaluated for antifungal activity, water solubility and acute toxicity in mice. They showed in vitro antifungal activity superior to pradimicin A. N,N-Dimethylpradimicins E and FA-2 showed great improvement in water solubility and animal tolerance. N,N-Dimethylpradimicin FA-2 was effective in 3 experimental in vivo fungal infection models.Entities:
Mesh：
Substances：
Year: 1990 PMID： 2132569 DOI： 10.7164/antibiotics.43.1230
Source DB: PubMed Journal: J Antibiot (Tokyo) ISSN： 0021-8820 Impact factor: 2.649