| Literature DB >> 21321567 |
André M Faria1, Ricardo V Perez, José A M Marcondes, Daniel S Freire, Roberto Blasbalg, José Soares, Kleber Simões, Sylvia A Y Hayashida, Maria A A Pereira.
Abstract
BACKGROUND: A 33-year-old woman presented to an endocrinology clinic with a 5-year history of secondary amenorrhea. 2 years before presentation, she had noticed progressively worsening signs of virilization. INVESTIGATIONS: Measurement of levels of serum free and total testosterone, androstenedione, dehydroepiandrosterone sulfate and gonadotropins; transvaginal ultrasonography, abdominal and pelvic MRI and (18)F-fluorodeoxyglucose PET imaging. DIAGNOSIS: Virilization secondary to an ovarian Leydig cell tumor. MANAGEMENT: The patient underwent a left salpingo-oophorectomy that confirmed the diagnosis of a unilateral Leydig cell tumor. Complete normalization of androgens and gonadotropin levels was achieved after surgery.Entities:
Mesh：
Year: 2011 PMID： 21321567 DOI： 10.1038/nrendo.2011.15
Source DB: PubMed Journal: Nat Rev Endocrinol ISSN： 1759-5029 Impact factor: 43.330