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Literature DB >> 21318330

Aging affects human B cell responses.

Abstract

Aging represents a complex remodeling in which both innate and adaptive immunities deteriorate. Age-related changes in humoral immunity are responsible for the reduced vaccine responses observed in elderly individuals. Although T cell alterations play a significant role in age-related humoral immune changes, alterations in B cells also occur. We here provide an overview of age-related changes in B cell markers and functions. Our studies have shown that intrinsic changes in B cells with age contribute to reduced antibody responses such as those to the influenza vaccine.

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Year: 2011 PMID： 21318330 PMCID： PMC5560853 DOI： 10.1007/s10875-010-9501-7

Source DB: PubMed Journal: J Clin Immunol ISSN： 0271-9142 Impact factor: 8.317

82 in total

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Authors: Albert C Shaw; Samit Joshi; Hannah Greenwood; Alexander Panda; Janet M Lord
Journal: Curr Opin Immunol Date: 2010-08 Impact factor: 7.486

9. Human uracil-DNA glycosylase deficiency associated with profoundly impaired immunoglobulin class-switch recombination.

Authors: Kohsuke Imai; Geir Slupphaug; Wen-I Lee; Patrick Revy; Shigeaki Nonoyama; Nadia Catalan; Leman Yel; Monique Forveille; Bodil Kavli; Hans E Krokan; Hans D Ochs; Alain Fischer; Anne Durandy
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Journal: J Exp Med Date: 2003-04-07 Impact factor: 14.307

55 in total

1. Prolonged proinflammatory cytokine production in monocytes modulated by interleukin 10 after influenza vaccination in older adults.

Authors: Subhasis Mohanty; Samit R Joshi; Ikuyo Ueda; Jean Wilson; Tamara P Blevins; Barbara Siconolfi; Hailong Meng; Lesley Devine; Khadir Raddassi; Sui Tsang; Robert B Belshe; David A Hafler; Susan M Kaech; Steven H Kleinstein; Mark Trentalange; Heather G Allore; Albert C Shaw
Journal: J Infect Dis Date: 2014-11-02 Impact factor: 5.226

2. Mechanistic insights into the impairment of memory B cells and antibody production in the elderly.

Authors: Judith H Aberle; Karin Stiasny; Michael Kundi; Franz X Heinz
Journal: Age (Dordr) Date: 2012-01-27

Review 3. Age effects on mouse and human B cells.

Authors: Bonnie B Blomberg; Daniela Frasca
Journal: Immunol Res Date: 2013-12 Impact factor: 2.829

4. Limited efficacy of inactivated influenza vaccine in elderly individuals is associated with decreased production of vaccine-specific antibodies.

Authors: Sanae Sasaki; Meghan Sullivan; Carlos F Narvaez; Tyson H Holmes; David Furman; Nai-Ying Zheng; Madhuri Nishtala; Jens Wrammert; Kenneth Smith; Judith A James; Cornelia L Dekker; Mark M Davis; Patrick C Wilson; Harry B Greenberg; Xiao-Song He
Journal: J Clin Invest Date: 2011-07-25 Impact factor: 14.808

5. Cytokine production in whole-blood cultures following immunization with an influenza vaccine.

Authors: Tetsuo Nakayama; Takuji Kumagai; Yasuyo Kashiwagi; Hironori Yoshii; Kenta Honjo; Ritsuko Kubota-Koketsu; Yoshinobu Okuno; Shigeru Suga
Journal: Hum Vaccin Immunother Date: 2018-08-28 Impact factor: 3.452

Review 6. The ageing haematopoietic stem cell compartment.

Authors: Hartmut Geiger; Gerald de Haan; M Carolina Florian
Journal: Nat Rev Immunol Date: 2013-04-15 Impact factor: 53.106

Review 7. Immunosenescence: the Role of Aging in the Predisposition to Neuro-Infectious Complications Arising from the Treatment of Multiple Sclerosis.

Authors: Elena Grebenciucova; Joseph R Berger
Journal: Curr Neurol Neurosci Rep Date: 2017-08 Impact factor: 5.081