OBJECTIVE: We sought to characterize serum angiogenic factor profile of women with complete placenta previa and determine if invasive trophoblast differentiation characteristic of accreta, increta, or percreta shares features of epithelial-to-mesenchymal transition. STUDY DESIGN: We analyzed gestational age-matched serum samples from 90 pregnant women with either complete placenta previa (n = 45) or uncomplicated pregnancies (n = 45). Vascular endothelial growth factor (VEGF), placental growth factor, and soluble form of fms-like-tyrosine-kinase-1 were immunoassayed. VEGF and phosphotyrosine immunoreactivity was surveyed in histological specimens relative to expression of vimentin and cytokeratin-7. RESULTS: Women with previa and invasive placentation (accreta, n = 5; increta, n = 6; percreta, n = 2) had lower systemic VEGF (invasive previa: median 0.8 [0.02-3.4] vs control 6.5 [2.7-10.5] pg/mL, P = .02). VEGF and phosphotyrosine immunostaining predominated in the invasive extravillous trophoblasts that coexpressed vimentin and cytokeratin-7, an epithelial-to-mesenchymal transition feature and tumorlike cell phenotype. CONCLUSION: Lower systemic free VEGF and a switch of the interstitial extravillous trophoblasts to a metastable cell phenotype characterize placenta previa with excessive myometrial invasion. Published by Mosby, Inc.
OBJECTIVE: We sought to characterize serum angiogenic factor profile of women with complete placenta previa and determine if invasive trophoblast differentiation characteristic of accreta, increta, or percreta shares features of epithelial-to-mesenchymal transition. STUDY DESIGN: We analyzed gestational age-matched serum samples from 90 pregnant women with either complete placenta previa (n = 45) or uncomplicated pregnancies (n = 45). Vascular endothelial growth factor (VEGF), placental growth factor, and soluble form of fms-like-tyrosine-kinase-1 were immunoassayed. VEGF and phosphotyrosine immunoreactivity was surveyed in histological specimens relative to expression of vimentin and cytokeratin-7. RESULTS:Women with previa and invasive placentation (accreta, n = 5; increta, n = 6; percreta, n = 2) had lower systemic VEGF (invasive previa: median 0.8 [0.02-3.4] vs control 6.5 [2.7-10.5] pg/mL, P = .02). VEGF and phosphotyrosine immunostaining predominated in the invasive extravillous trophoblasts that coexpressed vimentin and cytokeratin-7, an epithelial-to-mesenchymal transition feature and tumorlike cell phenotype. CONCLUSION: Lower systemic free VEGF and a switch of the interstitial extravillous trophoblasts to a metastable cell phenotype characterize placenta previa with excessive myometrial invasion. Published by Mosby, Inc.
Authors: H J van Beekhuizen; I Joosten; A N J A de Groot; F K Lotgering; J van der Laak; J Bulten Journal: J Clin Pathol Date: 2009-09 Impact factor: 3.411
Authors: Makrina D Savvidou; Christina K Yu; Lisa C Harland; Aroon D Hingorani; Kypros H Nicolaides Journal: Am J Obstet Gynecol Date: 2006-04-27 Impact factor: 8.661
Authors: Margreet Plaisier; Sharon Rodrigues; Florian Willems; Pieter Koolwijk; Victor W M van Hinsbergh; Frans M Helmerhorst Journal: Fertil Steril Date: 2007-03-26 Impact factor: 7.329
Authors: D J Lyell; A M Faucett; R J Baer; Y J Blumenfeld; M L Druzin; Y Y El-Sayed; G M Shaw; R J Currier; L L Jelliffe-Pawlowski Journal: J Perinatol Date: 2015-04-30 Impact factor: 2.521
Authors: Jelena Krstic; Alexander Deutsch; Julia Fuchs; Martin Gauster; Tina Gorsek Sparovec; Ursula Hiden; Julian Christopher Krappinger; Gerit Moser; Katrin Pansy; Marta Szmyra; Daniela Gold; Julia Feichtinger; Berthold Huppertz Journal: Biomedicines Date: 2022-05-04
Authors: Nicholas P Illsley; Sonia C DaSilva-Arnold; Stacy Zamudio; Manuel Alvarez; Abdulla Al-Khan Journal: Placenta Date: 2020-01-10 Impact factor: 3.481
Authors: Hacer Uyanıkoğlu; Adnan İncebıyık; Ahmet B Turp; Güler Çakmak; Sibel Sak; Neşe G Hilali Journal: Balkan Med J Date: 2017-09-13 Impact factor: 2.021